3-amino-5-chloro-1-methyl-2(1H)-Pyridinone

Base Information

• Chemical Name: 3-amino-5-chloro-1-methyl-2(1H)-Pyridinone
• CAS No.: 1441769-24-9
• Molecular Formula: C6H7ClN2O
• Molecular Weight: 158.587
• Hs Code.: 2933399990
• Mol file: 1441769-24-9.mol

Synonyms:3-amino-5-chloro-1-methyl-2(1H)-Pyridinone;3-amino-5-chloro-1-methylpyridin-2(1H)-one;3-amino-5-chloro-1-methyl-1H-pyridin-2-one

Chemical Property of 3-amino-5-chloro-1-methyl-2(1H)-Pyridinone

Chemical Property:

• PSA: 48.02000
• LogP: 1.20210

Purity/Quality:

99% ^*data from raw suppliers

3-Amino-5-chloro-1-methyl-2(1H)-pyridinone 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-amino-5-chloro-1-methyl-2(1H)-Pyridinone

There total 3 articles about 3-amino-5-chloro-1-methyl-2(1H)-Pyridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-chloro-1-methyl-3-nitro-1H-pyridin-2-one → 3-amino-5-chloro-1-methyl-1H-pyridin-2-one (1441769-24-9)

Guidance literature:

With hydrogen; In methanol; ethanol; at 20 ℃; for 8h;

Reference yield:

5-chloro-3-nitropyridin-2-ol (21427-61-2) → 3-amino-5-chloro-1-methyl-1H-pyridin-2-one (1441769-24-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 5 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: hydrogen / tetrahydrofuran; methanol / 16.5 h / 20 °C / Inert atmosphere

With hydrogen; sodium hydride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

→ 3-amino-5-chloro-1-methyl-1H-pyridin-2-one (1441769-24-9)

Guidance literature:

With hydrogen; In methanol; ethanol; at 20 ℃; for 97h;

upstream raw materials:

5-chloro-3-nitropyridin-2-ol

Downstream raw materials:

2-bromo-5-[(5-chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-ylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester

(6S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-(propan-2-yl)-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one

5-(5-chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-6-(4-chloro-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

2-bromo-5-(5-chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

Refernces

• 1、 -. "SUBSTITUTED PURINONE COMPOUNDS". Page/Page column 75. . Retrieved 2014/08/07.
• 2、 -. "IMIDAZOPYRROLIDINONE COMPOUNDS". Page/Page column 204; 205. . Retrieved 2013/08/15.