5-Chloro-2-hydroxy-3-nitropyridine

Base Information

• Chemical Name: 5-Chloro-2-hydroxy-3-nitropyridine
• CAS No.: 21427-61-2
• Molecular Formula: C5H3ClN2O3
• Molecular Weight: 174.543
• Hs Code.: 29337900
• Mol file: 21427-61-2.mol

Synonyms:2-Pyridinol,5-chloro-3-nitro- (8CI);2-Hydroxy-3-nitro-5-chloropyridine;5-Chloro-3-nitro-2-pyridinol;NSC 64258;

Chemical Property of 5-Chloro-2-hydroxy-3-nitropyridine

Chemical Property:

• Appearance/Colour: yellow solid
• Vapor Pressure: 0.00303mmHg at 25°C
• Melting Point: 234 °C
• Refractive Index: 1.602
• Boiling Point: 316 °C at 760 mmHg
• PKA: 6.31±0.10(Predicted)
• Flash Point: 125.6 °C
• PSA: 78.94000
• Density: 1.664 g/cm³
• LogP: 1.87200
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: soluble in Dimethylformamide

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-2-hydroxy-3-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39-39-36-37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 5-Chloro-2-hydroxy-3-nitropyridine (cas# 21427-61-2) is a compound useful in organic synthesis.

Technology Process of 5-Chloro-2-hydroxy-3-nitropyridine

There total 9 articles about 5-Chloro-2-hydroxy-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.5%

5-chloro-2-pyridylamine (1072-98-6) → 5-chloro-3-nitropyridin-2-ol (21427-61-2)

Guidance literature:

With sulfuric acid; nitric acid; sodium nitrite; In ice-water; water;

Reference yield: 17.0%

5-chloro-1,2-dihydropyridin-2-one (4214-79-3) → 5-chloro-3-nitropyridin-2(1H)-one (21427-61-2)

Guidance literature:

With sulfuric acid; sulfur trioxide; nitric acid; at 20 ℃; for 3h;

DOI:10.1016/j.bmc.2004.03.023

Reference yield:

2-amino-5-chloro-3-nitropyridine (5409-39-2) → 5-chloro-3-nitropyridin-2(1H)-one (21427-61-2) + 2,5-dichloro-3-nitropyridine (21427-62-3)

Guidance literature:

With hydrogenchloride; sodium nitrite; at -15 ℃;

DOI:10.1016/j.bmc.2004.03.023

upstream raw materials:

5-chloro-2-pyridylamine

2-amino-5-chloro-3-nitropyridine

sulfuric acid

nitric acid

Downstream raw materials:

3-amino-5-chloro-2-hydroxypyridine

2,5-dichloro-3-nitropyridine

2-bromo-5-chloro-3-nitropyridine

3-amino-2,5-dichloropyridine

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