Tafluprost ethyl ester

Base Information

Chemical Name:Tafluprost ethyl ester
CAS No.:209860-89-9
Molecular Formula:C24H32F2O5
Molecular Weight:438.5
Hs Code.:
UNII:WE6T2PLV6M
Nikkaji Number:J1.975.793E
Wikidata:Q104438897
Mol file:209860-89-9.mol

Synonyms:1-ethyl (5Z)-7-((1R,2R, 3R,5S)-2-((1E)-3,3-difluoro-4-phenoxy -1-butenyl)-3,5-dihydroxycyclopentyl)-5-heptenoate;AFP-175

Suppliers and Price of Tafluprost ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
Tafluprost ethyl ester ≥98%
5mg
$ 405.00

Cayman Chemical
Tafluprost ethyl ester ≥98%
10mg
$ 718.00

Cayman Chemical
Tafluprost ethyl ester ≥98%
1mg
$ 91.00

AK Scientific
Tafluprostethylester
10mg
$ 996.00

AK Scientific
Tafluprostethylester
5mg
$ 604.00

AK Scientific
Tafluprostethylester
1mg
$ 212.00

Total 8 raw suppliers

Chemical Property of Tafluprost ethyl ester

Chemical Property:

Boiling Point:546.6±50.0 °C(Predicted)
PKA:14.48±0.70(Predicted)
PSA：75.99000
Density:1.202±0.06 g/cm3(Predicted)
LogP:4.29450
XLogP3:4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:13
Exact Mass:438.22178044
Heavy Atom Count:31
Complexity:587

Purity/Quality:

98% ^*data from raw suppliers

Tafluprost ethyl ester ≥98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CCCC=CCC1C(CC(C1C=CC(COC2=CC=CC=C2)(F)F)O)O
Isomeric SMILES:CCOC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/C(COC2=CC=CC=C2)(F)F)O)O

Technology Process of Tafluprost ethyl ester

There total 2 articles about Tafluprost ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 118026-77-0
(4-carboethoxybutyl)-triphenylphosphonium bromide

: 209861-02-9
(3aR,4R,5R,6aS)-4-((E)-3,3-difluoro-4-phenoxybut-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2,5-diol

: 209860-89-9
1-(5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenylamino-1-butenyl]-dihydroxycyclopentyl}-5-ethylheptenoate

Guidance literature:: (4-carboethoxybutyl)-triphenylphosphonium bromide; With sodium hexamethyldisilazane; In tetrahydrofuran; at -10 - 20 ℃; Inert atmosphere;

(3aR,4R,5R,6aS)-4-((E)-3,3-difluoro-4-phenoxybut-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2,5-diol; In tetrahydrofuran; at -10 - 0 ℃; Inert atmosphere;

Reference yield:

: 14660-52-7
ethyl 5-bromovalerate

: 209860-89-9
1-(5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenylamino-1-butenyl]-dihydroxycyclopentyl}-5-ethylheptenoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene / 48 h / Inert atmosphere; Reflux

2.1: sodium hexamethyldisilazane / tetrahydrofuran / -10 - 20 °C / Inert atmosphere

2.2: -10 - 0 °C / Inert atmosphere

With sodium hexamethyldisilazane; In tetrahydrofuran; toluene;