118026-77-0

Upstream product

• 14660-52-7 ethyl 5-bromovalerate 
• 603-35-0 triphenylphosphine 

Downstream Products

• 209860-89-9 1-(5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenylamino-1-butenyl]-dihydroxycyclopentyl}-5-ethylheptenoate 
• 405925-58-8 Ethyl 6-[1-(triphenylmethyl)-1H-imidazol-4-yl]-5-Z-hexenoate 

Relevant academic research and scientific papers

Preparation method of high-purity Tafluprost and analogs thereof and intermediate compound

The invention belongs to the technical field of medicine, and relates to a preparation method of Tafluprost and analogs thereof and a related intermediate compound. The preparation method is characterized in that (4-carboxybutyl)triphenylphosphonium bromide having a structure shown below is used as a witting reaction reagent, wherein R is alkyl or aryl. The method is simple, feasible and convenient for industrial production; and the Tafluprost and analogs thereof which are basically free of omega chain trans-isomers can be prepared.