2-Fluoro-5-(Methoxycarbonyl)benzeneboronic acid pinacol ester, 96%

Base Information

• Chemical Name: 2-Fluoro-5-(Methoxycarbonyl)benzeneboronic acid pinacol ester, 96%
• CAS No.: 757982-31-3
• Molecular Formula: C14H20BFO5
• Molecular Weight: 280.104
• Mol file: 757982-31-3.mol

Synonyms:2-Fluoro-5-(Methoxycarbonyl)benzeneboronic acid pinacol ester, 96%;methyl 4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

Chemical Property of 2-Fluoro-5-(Methoxycarbonyl)benzeneboronic acid pinacol ester, 96%

Chemical Property:

• Melting Point: 100-102℃
• PSA: 44.76000
• LogP: 1.91150

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluoro-5-(Methoxycarbonyl)benzeneboronic acid pinacol ester, 96%

There total 4 articles about 2-Fluoro-5-(Methoxycarbonyl)benzeneboronic acid pinacol ester, 96% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

methyl 4-flurobenzoate (403-33-8) + bis(pinacol)diborane (73183-34-3) → methyl 4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (757982-31-3)

Guidance literature:

With n-butyllithium; C₂₈H₄₁ClNPPtSi; In hexane; 1,3,5-trimethyl-benzene; at 20 - 150 ℃; for 4h; regioselective reaction; Inert atmosphere;

DOI:10.1039/c5cc07263h

Reference yield:

bis(pinacol)diborane (73183-34-3) + methyl 3-bromo-4-fluorobenzoate (82702-31-6) → methyl 4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (757982-31-3)

Guidance literature:

With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; dimethyl sulfoxide; at 80 ℃; for 2h;

Reference yield:

methyl 4-flurobenzoate (403-33-8) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → methyl 4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (757982-31-3)

Guidance literature:

With 1,2,3-trimethoxybenzene; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 3,4,7,8-Tetramethyl-o-phenanthrolin; In 2-methyltetrahydrofuran; at 80 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jacs.1c00523

upstream raw materials:

bis(pinacol)diborane

methyl 3-bromo-4-fluorobenzoate

methyl 4-flurobenzoate

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

Downstream raw materials:

(2-fluoro-5-(methoxycarbonyl)-phenyl)boronic acid

methyl 4-flurobenzoate

4-Fluoro-3-hydroxy-benzoic acid methyl ester

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