2-(Difluoromethyl)benzaldehyde

Base Information

• Chemical Name: 2-(Difluoromethyl)benzaldehyde
• CAS No.: 1018678-50-6
• Molecular Formula: C8H6F2O
• Molecular Weight: 156.132
• Hs Code.: 2913000090
• Mol file: 1018678-50-6.mol

Synonyms:2-(Difluoromethyl)benzaldehyde;2-Formylbenzal fluoride, alpha,alpha-Difluoro-o-tolualdehyde

Chemical Property of 2-(Difluoromethyl)benzaldehyde

Chemical Property:

• Boiling Point: 217.5±35.0 °C(Predicted)
• PSA: 17.07000
• Density: 1.209±0.06 g/cm3(Predicted)
• LogP: 2.43670
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(Difluoromethyl)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Difluoromethyl)benzaldehyde

There total 6 articles about 2-(Difluoromethyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-bromo-2-(difluoromethyl)benzene (845866-82-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-(difluoromethyl)benzaldehyde (1018678-50-6)

Guidance literature:

1-bromo-2-(difluoromethyl)benzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

N,N-dimethyl-formamide; In tetrahydrofuran; at -40 ℃; for 1h;

Reference yield: 94.0%

1-bromo-2-(difluoromethyl)benzene (845866-82-2) → 2-(difluoromethyl)benzaldehyde (1018678-50-6)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 - -40 ℃; for 1.5h;

Reference yield: 70.0%

2-iodobenzaldehyde (26260-02-6) + tributyl(difluoromethyl)stannane (1438388-96-5) → 2-(difluoromethyl)benzaldehyde (1018678-50-6)

Guidance literature:

With potassium fluoride; copper(l) iodide; In N,N-dimethyl acetamide; at 100 ℃; for 24h; Inert atmosphere; Glovebox; Darkness;

DOI:10.1002/anie.201205850

upstream raw materials:

[2-(difluoromethyl)phenyl]methanol

1-bromo-2-(difluoromethyl)benzene

N,N-dimethyl-formamide

2-iodobenzaldehyde

Downstream raw materials:

[2-(difluoromethyl)phenyl]methanol

1-(chloromethyl)-2-(difluoromethyl)benzene

(S)-N-[(E)-2,2-difluoro-1-phenylethylidene]-2-phenylethylamine

4-(2-Difluoromethoxy-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

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