3,5-Pyridinedicarboxylic acid, 4-[2-(difluoromethoxy)phenyl]-1,4-dihydro-, diethyl ester

Base Information

• Chemical Name: 3,5-Pyridinedicarboxylic acid, 4-[2-(difluoromethoxy)phenyl]-1,4-dihydro-, diethyl ester
• CAS No.: 120533-64-4
• Molecular Formula: C₁₈H₁₉F₂NO₅
• Molecular Weight: 367.349
• Mol file: 120533-64-4.mol

Synonyms:

Chemical Property of 3,5-Pyridinedicarboxylic acid, 4-[2-(difluoromethoxy)phenyl]-1,4-dihydro-, diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Pyridinedicarboxylic acid, 4-[2-(difluoromethoxy)phenyl]-1,4-dihydro-, diethyl ester

There total 1 articles about 3,5-Pyridinedicarboxylic acid, 4-[2-(difluoromethoxy)phenyl]-1,4-dihydro-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

2-(difluoromethyl)benzaldehyde (1018678-50-6) + propynoic acid ethyl ester (623-47-2) → 4-(2-Difluoromethoxy-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester (120533-64-4)

Guidance literature:

With ammonium acetate;

DOI:10.1007/BF00474047

Reference yield: 65.0%

4-(2-Difluoromethoxy-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester (120533-64-4) → 4-(2-Difluoromethoxy-phenyl)-5-ethoxythiocarbonyl-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester + 4-(2-Difluoromethoxy-phenyl)-1,4-dihydro-pyridine-3,5-dicarbothioic acid di-O-ethyl ester (120533-72-4)

Guidance literature:

With Lawessons reagent; In xylene; for 25h; Heating;

DOI:10.1007/BF00474047

Reference yield:

4-(2-Difluoromethoxy-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester (120533-64-4) → 4-(2-Difluoromethoxy-phenyl)-1-methyl-1,4-dihydro-pyridine-3,5-dicarbothioic acid di-O-ethyl ester (120533-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / Lawesson's reagent / xylene / 25 h / Heating

2: 1. KOH / 1. 1,2-dimethoxyethane, reflux, 5 min; 2. reflux, 5 min

With Lawessons reagent; potassium hydroxide; In xylene;

DOI:10.1007/BF00474047

upstream raw materials:

2-(difluoromethyl)benzaldehyde

propynoic acid ethyl ester

Downstream raw materials:

4-(2-Difluoromethoxy-phenyl)-1,4-dihydro-pyridine-3,5-dicarbothioic acid di-O-ethyl ester

4-(2-Difluoromethoxy-phenyl)-1-methyl-1,4-dihydro-pyridine-3,5-dicarbothioic acid di-O-ethyl ester

Refernces