ETHYL 4-(CYCLOHEXYLAMINO)BENZOATE

Base Information

• Chemical Name: ETHYL 4-(CYCLOHEXYLAMINO)BENZOATE
• CAS No.: 102004-72-8
• Molecular Formula: C15H21NO2
• Molecular Weight: 247.337
• Mol file: 102004-72-8.mol

Synonyms:ETHYL 4-(CYCLOHEXYLAMINO)BENZOATE;UKRORGSYN-BB BBV-2075998

Chemical Property of ETHYL 4-(CYCLOHEXYLAMINO)BENZOATE

Chemical Property:

• Boiling Point: 215 - 218 °C (10 mmHg)
• PSA: 38.33000
• LogP: 3.68090

Purity/Quality:

Ethyl4-(Cyclohexylamino)benzoate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 4-(CYCLOHEXYLAMINO)BENZOATE

There total 6 articles about ETHYL 4-(CYCLOHEXYLAMINO)BENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

4-carbethoxyphenyl-4-tolylazo sulfone (105230-46-4) + dicyclohexylzinc(II) (15658-08-9) → 4-cyclohexylamino-benzoic acid ethyl ester (102004-72-8)

Guidance literature:

4-carbethoxyphenyl-4-tolylazo sulfone; dicyclohexylzinc(II); In tetrahydrofuran; at -20 ℃; for 0.5h;

With nickel; In ethanol; water; for 3h; Heating;

DOI:10.1021/ol061303m

Reference yield: 50.0%

1-bromocyclohexane (108-85-0) + p-aminoethylbenzoate (94-09-7) → 4-cyclohexylamino-benzoic acid ethyl ester (102004-72-8)

Guidance literature:

With potassium iodide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1039/c8ob00546j

Reference yield: 23.0%

Ethyl 4-hydroxybenzoate (120-47-8) + phenol (108-95-2,27073-41-2) → N-phenyl-2-cyclohexylamine (1821-36-9) + C15H21NO2 + C18H25NO4 + 4-cyclohexylamino-benzoic acid ethyl ester (102004-72-8)

Guidance literature:

With palladium on activated carbon; sodium formate; hydrazine hydrate; trifluoroacetic acid; In toluene; at 150 ℃; for 24h; Mechanism; Sealed tube; Inert atmosphere;

DOI:10.1002/adsc.201700712

upstream raw materials:

1-bromocyclohexane

p-aminoethylbenzoate

4-carbethoxyphenyl-4-tolylazo sulfone

dicyclohexylzinc(II)

Refernces

• 1、 Li, Jiang-Sheng,Qiu, Zihang,Li, Chao-Jun. "Palladium-Catalyzed Synthesis of N-Cyclohexyl Anilines from Phenols with Hydrazine or Hydroxylamine via N-N/O Cleavage". supporting information. p. 3648 - 3653. Retrieved 2017/09/13.
• 2、 Sinha, Pradipta,Kofink, Christiane C.,Knochel, Paul. "Preparation of aryl-alkylamines via electrophilic amination of functionalized arylazo tosylates with alkylzinc reagents". . p. 3741 - 3744. Retrieved 2007/10/03.