diglycyl-histidine

Base Information

• Chemical Name: diglycyl-histidine
• CAS No.: 7451-76-5
• Molecular Formula: C10H15 N5 O4
• Molecular Weight: 269.26
• Mol file: 7451-76-5.mol

Synonyms:Histidine,N-(N-glycylglycyl)-, L- (8CI); L-Histidine, N-(N-glycylglycyl)-; 168: PN:US20040018558 SEQID: 167 unclaimed protein; Diglycyl-L-histidine;Glycylglycyl-L-histidine; Glycylglycylhistidine; N-(N-Glycylglycyl)histidine;NSC 334195

Chemical Property of diglycyl-histidine

Chemical Property:

• Melting Point: >210 °C (decomp)
• Boiling Point: 813.8±65.0 °C(Predicted)
• PKA: 2.82±0.10(Predicted)
• PSA: 150.20000
• Density: 1.44
• LogP: -0.92140
• Storage Temp.: ?20°C

Purity/Quality:

99%+, ^*data from raw suppliers

Gly-Gly-His ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of diglycyl-histidine

There total 2 articles about diglycyl-histidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) + (9-fluorenylmethoxycarbonyl)-L-histidine (116611-64-4) → glycyl-glycyl-L-histidine (7451-76-5)

Guidance literature:

(9-fluorenylmethoxycarbonyl)-L-histidine; With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; Automated synthesizer; solid phase reaction;

With piperidine; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; for 0.216667h; Automated synthesizer; solid phase reaction;

N-(fluoren-9-ylmethoxycarbonyl)glycine; Further stages;

DOI:10.1002/chem.200701442

Reference yield:

→ glycyl-glycyl-L-histidine (7451-76-5)

Guidance literature:

Z-Gly-Gly-His-OH;

DOI:10.1246/bcsj.47.112

Reference yield:

glycyl-glycyl-L-histidine (7451-76-5) → glycylglycine (556-50-3) + L-histidine (71-00-1)

Guidance literature:

With (Et₂NH₂)₈[{α-PW₁₁O₃₉Zr-(μ-OH)(H₂O)}₂]*7H₂O; water; 3-(trimethylsilyl)propionic-2,2,3,3-d₄ acid sodium salt; In water-d2; at 60 ℃; Reagent/catalyst;

DOI:10.1002/ejic.201500161

upstream raw materials:

N-(fluoren-9-ylmethoxycarbonyl)glycine

(9-fluorenylmethoxycarbonyl)-L-histidine

Downstream raw materials:

Cu(H-2 glycylglycyl-L-histidine)(1-)

GH

glycine

glycylglycine

Refernces

• 1、 Yokoyama,Aiba,Tanaka. "Acid dissociation constants of some histidine containing peptides and formation constants of their metal complexes". . p. 112 - 117. Retrieved 2007/10/04.