KaeMpferol Di-O-MethoxyMethyl Ether

Base Information

• Chemical Name: KaeMpferol Di-O-MethoxyMethyl Ether
• CAS No.: 1329801-99-1
• Molecular Formula: C19H18O8
• Molecular Weight: 374.34
• Mol file: 1329801-99-1.mol

Synonyms:KaeMpferol Di-O-MethoxyMethyl Ether;3,5-Dihydroxy-7-(MethoxyMethoxy)-2-[4-(MethoxyMethoxy)phenyl]-4H-1-benzopyran-4-one

Chemical Property of KaeMpferol Di-O-MethoxyMethyl Ether

Chemical Property:

• PSA: 107.59000
• LogP: 2.83660
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly, Heated), Ethyl Acetate (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

Kaempferol Di-O-methoxymethyl Ether ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Kaempferol Di-O-methoxymethyl ether is a protected Kaempferol (K100000).

Technology Process of KaeMpferol Di-O-MethoxyMethyl Ether

There total 6 articles about KaeMpferol Di-O-MethoxyMethyl Ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-hydroxy-5,4',7-trimethoxymethylflavone → 3,5-hydroxy-4',7-dimethoxymethylflavone (1329801-99-1)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 20 ℃; for 0.5h;

DOI:10.1002/ejoc.201403689

Reference yield:

2,4,6-trihydroxyacetophenone (480-66-0,67471-34-5) → 3,5-hydroxy-4',7-dimethoxymethylflavone (1329801-99-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / acetone / 20 °C

2.1: potassium hydroxide / ethanol / 48 h / 20 °C

3.1: iodine / dimethyl sulfoxide / 24 h / Reflux

4.1: Oxone; sodium carbonate; sodium hydrogencarbonate / dichloromethane; acetone / 5 h / 0 °C

4.2: 0.5 h / 20 °C

5.1: hydrogenchloride / ethanol; water / 0.5 h / 20 °C

With hydrogenchloride; Oxone; iodine; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; potassium hydroxide; In ethanol; dichloromethane; water; dimethyl sulfoxide; acetone;

DOI:10.1002/ejoc.201403689

Reference yield:

4-methoxymethoxy-benzaldehyde (6515-21-5) → 3,5-hydroxy-4',7-dimethoxymethylflavone (1329801-99-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol / 48 h / 20 °C

2.1: iodine / dimethyl sulfoxide / 24 h / Reflux

3.1: Oxone; sodium carbonate; sodium hydrogencarbonate / dichloromethane; acetone / 5 h / 0 °C

3.2: 0.5 h / 20 °C

4.1: hydrogenchloride / ethanol; water / 0.5 h / 20 °C

With hydrogenchloride; Oxone; iodine; sodium hydrogencarbonate; sodium carbonate; potassium hydroxide; In ethanol; dichloromethane; water; dimethyl sulfoxide; acetone;

DOI:10.1002/ejoc.201403689

upstream raw materials:

2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone

2,4,6-trihydroxyacetophenone

4-methoxymethoxy-benzaldehyde

2'-hydroxy-4,4',6'-trimethoxymethoxylchalcone

Downstream raw materials:

3,4',7-tris-O-methoxymethylkaempferol

5-hydroxy-8-prenyl-3,4',7-tris-O-methoxymethylkaempferol

8-prenyl-3,7,4'-trihydroxy-5-methoxyflavone

8-prenylkaempferol

Refernces