O-Isobutyryl N-Methyl Naltrexone Iodide

Base Information

• Chemical Name: O-Isobutyryl N-Methyl Naltrexone Iodide
• CAS No.: 1048360-09-3
• Molecular Formula: C₂₅H₃₂NO₅*I
• Molecular Weight: 553.437
• Mol file: 1048360-09-3.mol

Synonyms:O-Isobutyryl N-Methyl Naltrexone Iodide;(5α)-17-(CyclopropylMethyl)-4,5-epoxy-14-hydroxy-17-Methyl-3-(2-Methyl-1-oxopropoxy)-6-oxo-MorphinaniuM Iodide

Chemical Property of O-Isobutyryl N-Methyl Naltrexone Iodide

Chemical Property:

• PSA: 72.83000
• LogP: -0.51140

Purity/Quality:

98% ^*data from raw suppliers

O-Isobutyryl N-Methyl Naltrexone Iodide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: As Naltrexone (N285750) derivative, O-Isobutyryl N-Methyl Naltrexone Iodide can be used in the preparation of nonselective opioid receptor antagonist.

Technology Process of O-Isobutyryl N-Methyl Naltrexone Iodide

There total 1 articles about O-Isobutyryl N-Methyl Naltrexone Iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-O-isobutyryl naltrexone (861238-38-2) + methyl iodide (74-88-4) → 3-O-(isobutyryl)-17-(cyclopropylmethyl)-4,5a-epoxy-14-hydroxy-6-N-methylmorphinan iodide (1048360-09-3)

Guidance literature:

at 88 - 90 ℃; for 17h; Cooling with liquid nitrogen;

Reference yield:

3-O-(isobutyryl)-17-(cyclopropylmethyl)-4,5a-epoxy-14-hydroxy-6-N-methylmorphinan iodide (1048360-09-3) → methylnaltrexone bromide (73232-52-7)

Guidance literature:

Multi-step reaction with 2 steps

1: bromo-type strongly basic anion exchange resin / water

2: hydrogen bromide / ethanol / 4 h / Reflux

With hydrogen bromide; In ethanol; water;

upstream raw materials:

3-O-isobutyryl naltrexone

methyl iodide

Downstream raw materials:

methylnaltrexone bromide

Refernces