3-Phenyl-4-trimethylsilyl-5,6,7,8-tetrahydro-isoquinoline

Base Information

Chemical Name:3-Phenyl-4-trimethylsilyl-5,6,7,8-tetrahydro-isoquinoline
CAS No.:440365-51-5
Molecular Formula:C₁₈H₂₃NSi
Molecular Weight:281.473
Hs Code.:
DSSTox Substance ID:DTXSID00464502
Nikkaji Number:J1.747.866D
Wikidata:Q82289844
Mol file:440365-51-5.mol

Synonyms:440365-51-5;3-Phenyl-4-(trimethylsilyl)-5,6,7,8-tetrahydroisoquinoline;3-PHENYL-4-TRIMETHYLSILYL-5,6,7,8-TETRAHYDRO-ISOQUINOLINE;DTXSID00464502

Suppliers and Price of 3-Phenyl-4-trimethylsilyl-5,6,7,8-tetrahydro-isoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 3-Phenyl-4-trimethylsilyl-5,6,7,8-tetrahydro-isoquinoline

Chemical Property:

PSA：12.89000
LogP:4.17260
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:281.159976272
Heavy Atom Count:20
Complexity:316

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C[Si](C)(C)C1=C2CCCCC2=CN=C1C3=CC=CC=C3

Technology Process of 3-Phenyl-4-trimethylsilyl-5,6,7,8-tetrahydro-isoquinoline

There total 4 articles about 3-Phenyl-4-trimethylsilyl-5,6,7,8-tetrahydro-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-47-0
benzonitrile

: C₁₄H₂₆Li₂Si₂

: 440365-51-5
3-phenyl-4-(trimethylsilyl)-5,6,7,8-tetrahydroisoquinoline

Guidance literature:: C₁₄H₂₆Li₂Si₂; With N,N,N,N,N,N-hexamethylphosphoric triamide; In diethyl ether; pentane; at 20 ℃; for 0.5h;

benzonitrile; In diethyl ether; at 20 ℃; for 1h;

With water; Further stages.;
DOI:10.1021/ja0262176

Reference yield:

: 100-47-0
benzonitrile

: C₁₄H₂₇LiSi₂

: 440365-51-5
3-phenyl-4-(trimethylsilyl)-5,6,7,8-tetrahydroisoquinoline

Guidance literature:: C₁₄H₂₇LiSi₂; With N,N,N,N,N,N-hexamethylphosphoric triamide; In diethyl ether; pentane; at 20 ℃; for 0.5h;

benzonitrile; In diethyl ether; pentane; at 20 ℃; for 1h; Further stages.;
DOI:10.1021/ja0262176

Reference yield:

: 219828-05-4
(1Z,3Z)-1,4-bis(trimethylsilyl)-2,3-tetramethylene-1,4-diiodobuta-1,3-diene

: 440365-51-5
3-phenyl-4-(trimethylsilyl)-5,6,7,8-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: t-BuLi / pentane / 1 h / -78 °C

2.1: HMPA / diethyl ether; pentane / 0.5 h / 20 °C

2.2: diethyl ether / 1 h / 20 °C

2.3: H₂O

With N,N,N,N,N,N-hexamethylphosphoric triamide; tert.-butyl lithium; In diethyl ether; pentane;
DOI:10.1021/ja0262176