5-Isoxazolecarboxylicacid,4,5-dihydro-3-(1-methylethyl)-,methylester(9CI)

Base Information

• Chemical Name: 5-Isoxazolecarboxylicacid,4,5-dihydro-3-(1-methylethyl)-,methylester(9CI)
• CAS No.: 162218-92-0
• Molecular Formula: C₈H₁₃NO₃
• Molecular Weight: 171.196
• Mol file: 162218-92-0.mol

Synonyms:5-Isoxazolecarboxylicacid,4,5-dihydro-3-(1-methylethyl)-,methylester(9CI)

Chemical Property of 5-Isoxazolecarboxylicacid,4,5-dihydro-3-(1-methylethyl)-,methylester(9CI)

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Isoxazolecarboxylicacid,4,5-dihydro-3-(1-methylethyl)-,methylester(9CI)

There total 3 articles about 5-Isoxazolecarboxylicacid,4,5-dihydro-3-(1-methylethyl)-,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-Isopropyl-2-(4-methoxy-benzyl)-isoxazolidine-5-carboxylic acid methyl ester (200352-43-8) → methyl 3-isopropyl-4,5-dihydroisoxazole-5-carboxylate (162218-92-0)

Guidance literature:

With triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; for 2h; Ambient temperature;

DOI:10.1021/jo971021n

Reference yield: 86.4%

isobutyraldehyde oxime (151-00-8) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 3-isopropyl-4,5-dihydroisoxazole-5-carboxylate (162218-92-0)

Guidance literature:

With oxone||potassium monopersulfate triple salt; sodium carbonate; sodium chloride; In water; acetonitrile; at 20 ℃; for 12h;

DOI:10.1021/acs.orglett.8b03829

Reference yield:

(1E)-2-methylpropanal oxime (5775-73-5) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 3-isopropyl-4,5-dihydroisoxazole-5-carboxylate (162218-92-0)

Guidance literature:

(1E)-2-methylpropanal oxime; With pyridine; N-chloro-succinimide; In chloroform; at 25 ℃; for 0.5h;

acrylic acid methyl ester; With triethylamine; In chloroform; at 25 ℃; for 16h;

upstream raw materials:

3-Isopropyl-2-(4-methoxy-benzyl)-isoxazolidine-5-carboxylic acid methyl ester

isobutyraldehyde oxime

acrylic acid methyl ester

(1E)-2-methylpropanal oxime