(4-phenyltetrahydro-2H-pyran-4-yl)amine(SALTDATA: HCl)

Base Information

• Chemical Name: (4-phenyltetrahydro-2H-pyran-4-yl)amine(SALTDATA: HCl)
• CAS No.: 14006-31-6
• Molecular Formula: C11H15NO
• Molecular Weight: 177.2429
• Hs Code.: 2932999099
• Mol file: 14006-31-6.mol

Synonyms:(4-phenyltetrahydro-2H-pyran-4-yl)amine(SALTDATA: HCl);Tetrahydro-4-phenyl-2H-pyran-4-aMine;4-phenyloxan-4-amine

Chemical Property of (4-phenyltetrahydro-2H-pyran-4-yl)amine(SALTDATA: HCl)

Chemical Property:

• Boiling Point: 284.6±40.0 °C(Predicted)
• PKA: 8.75±0.20(Predicted)
• PSA: 35.25000
• Density: 1.056±0.06 g/cm3(Predicted)
• LogP: 2.35130

Purity/Quality:

98%min ^*data from raw suppliers

4-Phenyloxan-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-phenyltetrahydro-2H-pyran-4-yl)amine(SALTDATA: HCl)

There total 4 articles about (4-phenyltetrahydro-2H-pyran-4-yl)amine(SALTDATA: HCl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H17NO2 (939801-34-0) → 4-phenyl-tetrahydro-pyran-4-ylamine (14006-31-6)

Guidance literature:

With diphenylsilane; titanium(IV)isopropoxide; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmcl.2008.09.042

Reference yield:

→ 4-phenyl-tetrahydro-pyran-4-ylamine (14006-31-6)

Guidance literature:

4-Carboxy-4-phenyl-tetrahydropyran, Benzol, konz.H2SO4, 50-55grad, NaN3, 50-55grad, 5.5 Std.;

DOI:10.1021/jm00313a042

Reference yield:

4-phenyltetrahydro-2H-pyran-4-carbonitrile (1202-81-9) → 4-phenyl-tetrahydro-pyran-4-ylamine (14006-31-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide / 3 h / 60 °C

2: sodium hydroxide; sodium chlorine monoxide / acetonitrile / 12 h / 0 - 20 °C / 760.05 Torr / pH 13

With sodium chlorine monoxide; dihydrogen peroxide; potassium carbonate; sodium hydroxide; In dimethyl sulfoxide; acetonitrile;

upstream raw materials:

C₁₃H₁₇NO₂

phenylacetonitrile

4-phenyltetrahydro-2H-pyran-4-carbonitrile

Downstream raw materials:

C₂₆H₃₃FN₂O₄

Refernces

• 1、 Nitta, Aiko,Fujii, Hideaki,Sakami, Satoshi,Nishimura, Yutaka,Ohyama, Tomofumi,Satoh, Mikiya,Nakaki, Junko,Satoh, Shiho,Inada, Chifumi,Kozono, Hideki,Kumagai, Hiroki,Shimamura, Masahiro,Fukazawa, Tominaga,Kawai, Hideki. "(3R)-3-Amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes". scheme or table. p. 5435 - 5438. Retrieved 2009/05/30.