4,7-Dichloro-2-phenylquinoline

Base Information

• Chemical Name: 4,7-Dichloro-2-phenylquinoline
• CAS No.: 116434-94-7
• Molecular Formula: C15H9Cl2N
• Molecular Weight: 274.149
• Mol file: 116434-94-7.mol

Synonyms:4,7-Dichloro-2-phenylquinoline

Chemical Property of 4,7-Dichloro-2-phenylquinoline

Chemical Property:

• Vapor Pressure: 1.64E-06mmHg at 25°C
• Boiling Point: 408.6°C at 760 mmHg
• Flash Point: 233.3°C
• PSA: 12.89000
• Density: 1.331g/cm³
• LogP: 5.20860

Purity/Quality:

98%min ^*data from raw suppliers

4,7-DICHLORO-2-PHENYLQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,7-Dichloro-2-phenylquinoline

There total 14 articles about 4,7-Dichloro-2-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

4-hydroxy-7-chloro-2-phenylquinoline (110802-16-9) → 4,7-dichloro-2-phenylquinoline (116434-94-7)

Guidance literature:

With trichlorophosphate; for 3h; Reflux;

Reference yield:

4,7-dichloroquinoline (86-98-6,1138471-54-1) + phenyllithium (591-51-5) → 4,7-dichloro-2-phenylquinoline (116434-94-7)

Guidance literature:

With diethyl ether; Mit Picrinsaeure in Aethanol und Erwaermen des erhaltenen Picrats mit wss.Ammoniak;

DOI:10.1021/ja01193a034

Reference yield:

N-(3-chlorophenyl)benzimidoyl chloride (34918-77-9) → 4,7-dichloro-2-phenylquinoline (116434-94-7)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene / Erhitzen des Reaktionsprodukts auf 190grad

2: aqueous NaOH

3: 360 °C

4: phosphoryl chloride

With sodium hydroxide; toluene; trichlorophosphate;

DOI:10.1021/ja01211a042

upstream raw materials:

4,7-dichloroquinoline

phenyllithium

4-hydroxy-7-chloro-2-phenylquinoline

N-(3-chlorophenyl)benzimidoyl chloride

Downstream raw materials:

N⁴-(7-chloro-2-phenylquinolin-4-yl)-N¹,N¹-diethylpentane-1,4-diamine