5-broMo-7-fluoro-1H-benzo[d]iMidazole

Base Information

• Chemical Name: 5-broMo-7-fluoro-1H-benzo[d]iMidazole
• CAS No.: 1197944-23-2
• Molecular Formula: C7H4BrFN2
• Molecular Weight: 215.025
• Hs Code.: 2933998090
• Mol file: 1197944-23-2.mol

Synonyms:5-broMo-7-fluoro-1H-benzo[d]iMidazole;6-Bromo-4-fluoro-1H-benzimidazole;5-Bromo-7-fluoro-1H-benzoimidazole

Chemical Property of 5-broMo-7-fluoro-1H-benzo[d]iMidazole

Chemical Property:

• Vapor Pressure: 0.0±0.9 mmHg at 25°C
• Boiling Point: 412.8±25.0 °C at 760 mmHg
• PKA: 10.23±0.30(Predicted)
• Flash Point: 203.4±23.2 °C
• PSA: 28.68000
• Density: 1.9±0.1 g/cm3
• LogP: 2.46450

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-7-fluoro-1H-benzo[d]imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-broMo-7-fluoro-1H-benzo[d]iMidazole

There total 3 articles about 5-broMo-7-fluoro-1H-benzo[d]iMidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

formic acid (64-18-6) + 5-bromo-3-fluoro-1,2-phenylenediamine (517920-69-3) → 5-bromo-7-fluoro-1H-benzo[d]imidazole (1197944-23-2)

Guidance literature:

Reflux;

Reference yield:

formic acid (64-18-6) + 5-bromo-3-fluoro-1,2-phenylenediamine (517920-69-3) → 6-bromo-4-fluoro-1H-benzo[d]imidazole (1197944-23-2)

Guidance literature:

at 100 ℃; for 3h; Inert atmosphere;

Reference yield:

4-Bromo-2-fluoro-6-nitrobenzenamine (517920-70-6) → 6-bromo-4-fluoro-1H-benzo[d]imidazole (1197944-23-2)

Guidance literature:

Multi-step reaction with 2 steps

1: iron; ammonium chloride / ethanol; tetrahydrofuran; water / 2 h / 90 °C

2: 3 h / 100 °C / Inert atmosphere

With iron; ammonium chloride; In tetrahydrofuran; ethanol; water;

upstream raw materials:

formic acid

5-bromo-3-fluoro-1,2-phenylenediamine

4-Bromo-2-fluoro-6-nitrobenzenamine