4-[(3,4-DICHLOROBENZYL)OXY]-3-METHOXYBENZALDEHYDE

Base Information

• Chemical Name: 4-[(3,4-DICHLOROBENZYL)OXY]-3-METHOXYBENZALDEHYDE
• CAS No.: 423151-49-9
• Molecular Formula: C15H12Cl2O3
• Molecular Weight: 311.16
• Mol file: 423151-49-9.mol

Synonyms:OTAVA-BB BB7018802000;ASISCHEM R26771;ART-CHEM-BB B014299;AKOS B014299;4-[(3,4-DICHLOROBENZYL)OXY]-3-METHOXYBENZALDEHYDE

Chemical Property of 4-[(3,4-DICHLOROBENZYL)OXY]-3-METHOXYBENZALDEHYDE

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

4-[(3,4-Dichlorobenzyl)oxy]-3-methoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 4-[(3,4-DICHLOROBENZYL)OXY]-3-METHOXYBENZALDEHYDE

There total 4 articles about 4-[(3,4-DICHLOROBENZYL)OXY]-3-METHOXYBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3,4-Dichlorophenylmethyl chloride (102-47-6) + vanillin (121-33-5,8014-42-4) → 4-(3,4-dichlorobenzyloxy)-3-methoxybenzaldehyde (423151-49-9)

Guidance literature:

With potassium carbonate; sodium iodide; In acetonitrile; Heating;

DOI:10.3390/70900697

Reference yield: 85.0%

4-(3,4-dichlorobenzyloxy)-3-hydroxybenzaldehyde + methyl iodide (74-88-4) → 4-(3,4-dichlorobenzyloxy)-3-methoxybenzaldehyde (423151-49-9)

Guidance literature:

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; water; at 20 ℃; for 24h;

DOI:10.3390/70900697

Reference yield:

3,4-Dichlorophenylmethyl chloride (102-47-6) → 4-(3,4-dichlorobenzyloxy)-3-methoxybenzaldehyde (423151-49-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / sodium iodide; sodium bicarbonate / dimethylformamide / 24 h / 40 °C

2: 85 percent / NaOH; Bu₄NHSO₄ / H₂O; tetrahydrofuran / 24 h / 20 °C

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; sodium iodide; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.3390/70900697

upstream raw materials:

3,4-Dichlorophenylmethyl chloride

vanillin

methyl iodide

3,4-dihydroxybenzaldehyde

Downstream raw materials:

N-(4-(3,4-dichlorobenzyloxy)-3-methoxybenzyl)-1-(pyridin-4-yl)methanamine