2'-Chloro-4'-fluoroacetanilide

Base Information

Chemical Name:2'-Chloro-4'-fluoroacetanilide
CAS No.:399-35-9
Molecular Formula:C8H7ClFNO
Molecular Weight:187.601
Hs Code.:29049095
DSSTox Substance ID:DTXSID40343387
Nikkaji Number:J265.909C
Wikidata:Q82114677
Mol file:399-35-9.mol

Synonyms:399-35-9;2'-Chloro-4'-fluoroacetanilide;N-(2-Chloro-4-fluorophenyl)acetamide;2-Chloro-4-fluoroacetanilide;Acetamide, N-(2-chloro-4-fluorophenyl)-;SCHEMBL1116498;ZULZFLOGABTQFR-UHFFFAOYSA-;AMY8854;DTXSID40343387;MFCD00042594;AKOS008922261;PS-8453;N-(2-Chloro-4-fluorophenyl)acetamide #;CS-0196436;FT-0611755;A824810

Suppliers and Price of 2'-Chloro-4'-fluoroacetanilide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-(2-Chloro-4-fluorophenyl)acetamide
500mg
$ 60.00

TCI Chemical
2'-Chloro-4'-fluoroacetanilide >98.0%(GC)
5g
$ 31.00

TCI Chemical
2'-Chloro-4'-fluoroacetanilide >98.0%(GC)
25g
$ 153.00

SynQuest Laboratories
2'-Chloro-4'-fluoroacetanilide 99%
250 g
$ 104.00

SynQuest Laboratories
2'-Chloro-4'-fluoroacetanilide 99%
50 g
$ 24.00

Matrix Scientific
2'-Chloro-4'-fluoroacetanilide 99%
25g
$ 48.00

Matrix Scientific
2'-Chloro-4'-fluoroacetanilide 99%
5g
$ 16.00

Crysdot
N-(2-Chloro-4-fluorophenyl)acetamide 95+%
100g
$ 90.00

American Custom Chemicals Corporation
2'-CHLORO-4'-FLUOROACETANILIDE 95.00%
250G
$ 4198.43

American Custom Chemicals Corporation
2'-CHLORO-4'-FLUOROACETANILIDE 95.00%
100G
$ 2385.08

Total 36 raw suppliers

Chemical Property of 2'-Chloro-4'-fluoroacetanilide

Chemical Property:

Appearance/Colour:grey needle-like crystalline powder
Melting Point:117-119 °C(lit.)
Boiling Point:314.3 °C at 760 mmHg
PKA:13.17±0.70(Predicted)
Flash Point:143.9 °C
PSA：29.10000
Density:1.352 g/cm³
LogP:2.51050
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:187.0200197
Heavy Atom Count:12
Complexity:176

Purity/Quality:

97% ^*data from raw suppliers

N-(2-Chloro-4-fluorophenyl)acetamide ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC1=C(C=C(C=C1)F)Cl

Technology Process of 2'-Chloro-4'-fluoroacetanilide

There total 4 articles about 2'-Chloro-4'-fluoroacetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 351-83-7
4'-fluoroacetanilide

: 399-35-9
N-(2-chloro-4-fluorophenyl)acetamide

Guidance literature:: With N-chloro-succinimide; In acetonitrile; for 2h; regioselective reaction; Irradiation;
DOI:10.1002/ejoc.201801097

Reference yield: 73.0%

: 2106-02-7
2-chloro-4-fluoroaniline

: 108-24-7
acetic anhydride

: 399-35-9
N-(2-chloro-4-fluorophenyl)acetamide

Guidance literature:: With dmap; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/acs.orglett.7b03909

Reference yield:

: 371-40-4
4-fluoroaniline

: 399-35-9
N-(2-chloro-4-fluorophenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 20 °C / Inert atmosphere

2: bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; N-tert-butoxycarbonyl-L-phenylalanine; silver(I) triflimide; N-chlorophthalimide / 1,2-dichloro-ethane / 6 h / 80 °C / Inert atmosphere; Sealed tube

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; N-chlorophthalimide; N-tert-butoxycarbonyl-L-phenylalanine; silver(I) triflimide; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1002/chem.201700280