tert-Butyl N-[2-(4-bromophenyl)-2-oxoethyl]carbamate

Base Information

• Chemical Name: tert-Butyl N-[2-(4-bromophenyl)-2-oxoethyl]carbamate
• CAS No.: 339185-70-5
• Molecular Formula: C13H16BrNO3
• Molecular Weight: 314.179
• Hs Code.: 2924299090
• Mol file: 339185-70-5.mol

Synonyms:tert-Butyl N-[2-(4-bromophenyl)-2-oxoethyl]carbamate;tert-butyl (2-(4-bromophenyl)-2-oxoethyl)carbamate;4-Bromophenacylamine,N-BOCprotected

Chemical Property of tert-Butyl N-[2-(4-bromophenyl)-2-oxoethyl]carbamate

Chemical Property:

• PSA: 55.40000
• LogP: 3.54740

Purity/Quality:

98%min ^*data from raw suppliers

4-Bromophenacylamine, N-Boc protected ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl N-[2-(4-bromophenyl)-2-oxoethyl]carbamate

There total 5 articles about tert-Butyl N-[2-(4-bromophenyl)-2-oxoethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + α-amino-4-bromoacetophenone hydrochloride (5467-72-1) → 1,1-dimethylethyl [2-(4-bromophenyl)-2-oxoethyl]carbamate (339185-70-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1016/j.bmcl.2010.06.134

Reference yield: 99.5%

di-tert-butyl dicarbonate (24424-99-5) → 1,1-dimethylethyl [2-(4-bromophenyl)-2-oxoethyl]carbamate (339185-70-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;

di-tert-butyl dicarbonate; In tetrahydrofuran; at 20 ℃; for 6h; Product distribution / selectivity;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 4-bromophenacylamine (7644-04-4) → 1,1-dimethylethyl [2-(4-bromophenyl)-2-oxoethyl]carbamate (339185-70-5)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm4013104

upstream raw materials:

di-tert-butyl dicarbonate

α-amino-4-bromoacetophenone hydrochloride

para-bromophenacyl bromide

4-bromophenacylamine

Downstream raw materials:

tert-butyl (2-(4-bromophenyl)-2-hydroxyethyl)carbamate

nicotinic acid 1-(4-bromo-phenyl)-2-tert-butoxycarbonylamino-ethyl ester

nicotinic acid 2-tert-butoxycarbonylamino-1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethyl ester

C₃₁H₄₃BN₄O₈

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