Carbamic acid, [5-oxo-5-[4-(trifluoromethyl)phenyl]pentyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [5-oxo-5-[4-(trifluoromethyl)phenyl]pentyl]-, 1,1-dimethylethyl ester
CAS No.:616226-82-5
Molecular Formula:C17H22F3NO3
Molecular Weight:345.3566896
Hs Code.:
Mol file:616226-82-5.mol

Synonyms:Carbamic acid, [5-oxo-5-[4-(trifluoromethyl)phenyl]pentyl]-, 1,1-dimethylethyl ester

Suppliers and Price of Carbamic acid, [5-oxo-5-[4-(trifluoromethyl)phenyl]pentyl]-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
[5-OXO-5-[4-(TRIFLUOROMETHYL)PHENYL]PENTYL]-CARBAMIC ACID-1,1-DIMETHYLETHYL ESTER 95.00%
5MG
$ 497.11

Total 2 raw suppliers

Chemical Property of Carbamic acid, [5-oxo-5-[4-(trifluoromethyl)phenyl]pentyl]-, 1,1-dimethylethyl ester

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:441.099°C at 760 mmHg
Flash Point:220.569°C
PSA：58.89000
Density:1.156g/cm³
LogP:4.78750

Purity/Quality:

99% ^*data from raw suppliers

[5-OXO-5-[4-(TRIFLUOROMETHYL)PHENYL]PENTYL]-CARBAMIC ACID-1,1-DIMETHYLETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [5-oxo-5-[4-(trifluoromethyl)phenyl]pentyl]-, 1,1-dimethylethyl ester

There total 4 articles about Carbamic acid, [5-oxo-5-[4-(trifluoromethyl)phenyl]pentyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 402-51-7
4-(trifluoromethyl)phenylmagnesium bromide

: 85908-96-9
2-oxopiperidine-1-carboxylic acid tert-butyl ester

: 616226-82-5
(5-oxo-5-(4-trifluoromethylphenyl)-pentyl)-carbamic acid tert-butyl ester

Guidance literature:: In tetrahydrofuran; at -78 - 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1021/jm2013634

Reference yield: 28.0%

: 402-43-7
p-trifluoromethylphenyl bromide

: 85908-96-9
2-oxopiperidine-1-carboxylic acid tert-butyl ester

: 616226-82-5
(5-oxo-5-(4-trifluoromethylphenyl)-pentyl)-carbamic acid tert-butyl ester

Guidance literature:: p-trifluoromethylphenyl bromide; With iodine; magnesium; In tetrahydrofuran; for 1h; Heating;

2-oxopiperidine-1-carboxylic acid tert-butyl ester; In tetrahydrofuran; at -70 - 20 ℃;
DOI:10.1021/ol035746r

Reference yield:

: 675-20-7
piperidin-2-one

: 616226-82-5
(5-oxo-5-(4-trifluoromethylphenyl)-pentyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / n-BuLi / CH₂Cl₂ / -78 - 20 °C

2.1: Mg; I₂ / tetrahydrofuran / 1 h / Heating

2.2: 28 percent / tetrahydrofuran / -70 - 20 °C

With n-butyllithium; iodine; magnesium; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol035746r