tert-butyl 4-(2-(2,6-dichlorobenzyl)-1H-imidazol-5-yl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(2-(2,6-dichlorobenzyl)-1H-imidazol-5-yl)piperidine-1-carboxylate
• CAS No.: 301221-80-7
• Molecular Formula: C₂₀H₂₅Cl₂N₃O₂
• Molecular Weight: 410.343
• Mol file: 301221-80-7.mol

Synonyms:tert-butyl 4-(2-(2,6-dichlorobenzyl)-1H-imidazol-5-yl)piperidine-1-carboxylate

Chemical Property of tert-butyl 4-(2-(2,6-dichlorobenzyl)-1H-imidazol-5-yl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(2-(2,6-dichlorobenzyl)-1H-imidazol-5-yl)piperidine-1-carboxylate

There total 3 articles about tert-butyl 4-(2-(2,6-dichlorobenzyl)-1H-imidazol-5-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate (139290-70-3) → 4-[2-(2,6-dichloro-benzyl)-3H-imidazol-4-yl]-piperidine-1-carboxylic acid tert-butyl ester (301221-80-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: diethyl ether

2.1: LDA; TMSCl

2.2: NBS

3.1: CHCl₃ / Heating

With chloro-trimethyl-silane; lithium diisopropyl amide; In diethyl ether; chloroform;

DOI:10.1016/j.bmcl.2004.04.078

Reference yield:

4-acetyl-1-(t-butoxycarbonyl)piperidine (206989-61-9) → 4-[2-(2,6-dichloro-benzyl)-3H-imidazol-4-yl]-piperidine-1-carboxylic acid tert-butyl ester (301221-80-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LDA; TMSCl

1.2: NBS

2.1: CHCl₃ / Heating

With chloro-trimethyl-silane; lithium diisopropyl amide; In chloroform;

DOI:10.1016/j.bmcl.2004.04.078

Reference yield:

2,6-dichlorobenzeneethanimidamide (78622-21-6) + 4-Bromoacetyl-1-(t-butoxycarbonyl)piperidine (301221-79-4) → 4-[2-(2,6-dichloro-benzyl)-3H-imidazol-4-yl]-piperidine-1-carboxylic acid tert-butyl ester (301221-80-7)

Guidance literature:

In chloroform; Heating;

DOI:10.1016/j.bmcl.2004.04.078

upstream raw materials:

2,6-dichlorobenzeneethanimidamide

4-Bromoacetyl-1-(t-butoxycarbonyl)piperidine

tert-butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

4-acetyl-1-(t-butoxycarbonyl)piperidine

Downstream raw materials:

4-(2-benzyl-3H-imidazol-4-yl)-piperidine-1-carboxylic acid tert-butyl ester

4-(2-benzyl-5-vinyl-3H-imidazol-4-yl)-piperidine-1-carboxylic acid tert-butyl ester

4-(2-benzyl-5-iodo-3H-imidazol-4-yl)-piperidine-1-carboxylic acid tert-butyl ester

4-(2-benzyl-5-chloro-3H-imidazol-4-yl)-piperidine-1-carboxylic acid tert-butyl ester