2-(2-Fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Base Information

• Chemical Name: 2-(2-Fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS No.: 1073353-89-5
• Molecular Formula: C12H15BFNO4
• Molecular Weight: 267.065
• Hs Code.: 2934999090
• Mol file: 1073353-89-5.mol

Synonyms:2-(2-Fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;2-Fluoro-4-nitrophenylboronic acid, pinacol ester;2-Fluoro-4-nitrobenzeneboronic acid pinacol ester, 96%

Chemical Property of 2-(2-Fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property:

• PSA: 64.28000
• LogP: 2.55630

Purity/Quality:

97% ^*data from raw suppliers

2-Fluoro-4-nitrophenylboronicAcidPinacolEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Fluoro-4-nitrophenylboronic acid, pinacol ester

Technology Process of 2-(2-Fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

There total 3 articles about 2-(2-Fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.6%

2-fluoro-1-iodo-4-nitrobenzene (2996-30-7) + bis(pinacol)diborane (73183-34-3) → 2-(2-fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1073353-89-5)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In dimethyl sulfoxide; at 100 ℃; for 2.5h; Sealed tube; Inert atmosphere;

Reference yield: 70.0%

bis(pinacol)diborane (73183-34-3) + 1-bromo-2-fluoro-4-nitrobenzene (185331-69-5) → 2-(2-fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1073353-89-5)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1039/d0cc06035f

Reference yield: 51.0%

2-fluoro-4-nitroaniline (369-35-7) + bis(pinacol)diborane (73183-34-3) → 2-(2-fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1073353-89-5)

Guidance literature:

With tert.-butylnitrite; 2-(4-biphenylyl)-5-phenyloxazole; In acetonitrile; at 20 ℃; for 4h;

DOI:10.1021/jo402618r

upstream raw materials:

bis(pinacol)diborane

1-bromo-2-fluoro-4-nitrobenzene

2-fluoro-4-nitroaniline

2-fluoro-1-iodo-4-nitrobenzene

Downstream raw materials:

2-(2-fluoro-4-nitrophenyl)-5-(2-isopropoxy-4-nitrophenyl)furan

C₁₉H₁₉FN₂O₂

C₃₁H₂₇FN₆O₂

3-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenylamine