2-hydroxy-6-methoxybenzonitrile

Base Information

• Chemical Name: 2-hydroxy-6-methoxybenzonitrile
• CAS No.: 71590-96-0
• Molecular Formula: C₈H₇NO₂
• Molecular Weight: 149.149
• Mol file: 71590-96-0.mol

Synonyms:2-hydroxy-6-methoxybenzonitrile

Chemical Property of 2-hydroxy-6-methoxybenzonitrile

Chemical Property:

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-hydroxy-6-methoxybenzonitrile

There total 6 articles about 2-hydroxy-6-methoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,6-dimethoxybenzonitrile (16932-49-3) → 2-hydroxy-6-methoxybenzonitrile (71590-96-0)

Guidance literature:

With 1,3-dimethyl-2-imidazolidinone; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at 185 ℃; for 12h; further reagent: NaN(SiMe₃)2;

DOI:10.1021/jo961191k

Reference yield: 81.0%

2-hydroxy-6-methoxybenzoic acid (3147-64-6) + N-cyano-N-phenyl-p-toluenesulfonamide (55305-43-6) → 2-hydroxy-6-methoxybenzonitrile (71590-96-0)

Guidance literature:

With palladium(II) trifluoroacetate; In dimethyl sulfoxide; N,N-dimethyl-formamide; at 120 ℃; for 3h;

DOI:10.1021/acs.joc.7b00033

Reference yield:

6-methoxysalicylaldehyde (700-44-7) → 2-hydroxy-6-methoxybenzonitrile (71590-96-0)

Guidance literature:

With Nitroethane; sodium acetate; acetic acid; Reflux;

DOI:10.1016/j.bmc.2008.08.029

upstream raw materials:

salicylonitrile

sodium ethanolate

methyl iodide

2,6-dimethoxybenzonitrile

Downstream raw materials:

(3-amino-4-methoxybenzofuran-2-yl)(3,4,5-trimethoxy-phenyl )methanone

2-(2-chlorophenyl)-9-(methyloxy)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one

C₁₀H₁₀N₂O₃

ravenelin