Afatinib IMpurity J

Base Information

Chemical Name:Afatinib IMpurity J
CAS No.:1456696-14-2
Molecular Formula:C18H22N4O4
Molecular Weight:358.397
Hs Code.:
Mol file:1456696-14-2.mol

Synonyms:Afatinib IMpurity J;Afatinib Impurity 10

Suppliers and Price of Afatinib IMpurity J

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2E)-N-[3,4-Dihydro-4-oxo-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
1mg
$ 165.00

Total 10 raw suppliers

Chemical Property of Afatinib IMpurity J

Chemical Property:

PKA:11.89±0.20(Predicted)
PSA：96.55000
Density:1.33±0.1 g/cm3(Predicted)
LogP:1.22010

Purity/Quality:

> 95% ^*data from raw suppliers

(2E)-N-[3,4-Dihydro-4-oxo-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (2E)-N-[3,4-Dihydro-4-oxo-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide, s an impurity of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

Technology Process of Afatinib IMpurity J

There total 1 articles about Afatinib IMpurity J which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53449-14-2
7-chloro-6-nitro-4(3H)-quinazolinone

: 1456696-14-2
(S,E)-4-(dimethylamino)-N-(4-oxo-7-((tetrahydrofuran-3-yl)oxy)-3,4-dihydroquinazolin-6-yl)but-2-enamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 6 h / 90 °C

2.1: potassium tert-butylate / N,N-dimethyl-formamide; tert-butyl alcohol; tetrahydrofuran / 20 - 45 °C / Inert atmosphere

3.1: iron; acetic acid / ethanol; water / 0.33 h / 110 °C

4.1: N,N-dimethyl-formamide; oxalyl dichloride / tetrahydrofuran / 1.5 h / 0 - 25 °C / Inert atmosphere

4.2: 0 - 20 °C

With oxalyl dichloride; potassium tert-butylate; iron; acetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1456696-14-2
(S,E)-4-(dimethylamino)-N-(4-oxo-7-((tetrahydrofuran-3-yl)oxy)-3,4-dihydroquinazolin-6-yl)but-2-enamide

: 906565-46-6
3-chloro-4-[¹⁸F]fluoroaniline

: 1621182-22-6
[¹⁸F](S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 0.5h;