2-Pyridinecarboxylic acid, 3-broMo-6-fluoro-, 1,1-diMethylethyl ester

Base Information

• Chemical Name: 2-Pyridinecarboxylic acid, 3-broMo-6-fluoro-, 1,1-diMethylethyl ester
• CAS No.: 1430753-76-6
• Molecular Formula: C10H11BrFNO2
• Molecular Weight: 276.105
• Mol file: 1430753-76-6.mol

Synonyms:2-Pyridinecarboxylic acid, 3-broMo-6-fluoro-, 1,1-diMethylethyl ester;tert-butyl 3-bromo-6-fluoropyridine-2-carboxylate;tert-Butyl 3-bromo-6-fluoropicolinate

Chemical Property of 2-Pyridinecarboxylic acid, 3-broMo-6-fluoro-, 1,1-diMethylethyl ester

Chemical Property:

• PSA: 39.19000
• LogP: 2.93850
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,?1-?DimethylethylEster3-?Bromo-?6-?fluoro-?2-pyridinecarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,?1-?Dimethylethyl Ester 3-?Bromo-?6-?fluoro-?2-pyridinecarboxylic Acid is a useful reagent in preparation of cell peremeable Bcl-xl inhibitor and antibody drug conjugates.

Technology Process of 2-Pyridinecarboxylic acid, 3-broMo-6-fluoro-, 1,1-diMethylethyl ester

There total 3 articles about 2-Pyridinecarboxylic acid, 3-broMo-6-fluoro-, 1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-6-fluoro-2-picolinic acid (1211589-43-3) + tert-butyl alcohol (75-65-0) → tert-butyl 3-bromo-6-fluoropicolinate (1430753-76-6)

Guidance literature:

With pyridine; p-toluenesulfonyl chloride; In dichloromethane; at 0 - 20 ℃;

Reference yield:

6-amino-3-bromopicolinic acid (1033201-61-4) → tert-butyl 3-bromo-6-fluoropicolinate (1430753-76-6)

Guidance literature:

Multi-step reaction with 2 steps

1: nitrosonium tetrafluoroborate / dichloromethane; chloroform / 5 - 35 °C

2: pyridine; p-toluenesulfonyl chloride / dichloromethane / 0 - 20 °C

With pyridine; nitrosonium tetrafluoroborate; p-toluenesulfonyl chloride; In dichloromethane; chloroform;

Reference yield:

→ tert-butyl 3-bromo-6-fluoropicolinate (1430753-76-6)

Guidance literature:

With pyridine; p-toluenesulfonyl chloride; In tert-butyl alcohol; at 0 - 20 ℃; for 12h;

upstream raw materials:

6-amino-3-bromopicolinic acid

3-bromo-6-fluoro-2-picolinic acid

tert-butyl alcohol

Refernces

• 1、 -. "ANTI-B7-H3 ANTIBODIES AND ANTIBODY DRUG CONJUGATES". . . Retrieved 2018/01/13.
• 2、 -. "ANTI-CD98 ANTIBODIES AND ANTIBODY DRUG CONJUGATES". . . Retrieved 2018/01/15.