1211589-43-3

Basic information

• Product Name: 3-Bromo-6-fluoropicolinic acid
• Synonyms: 3-Bromo-6-fluoropicolinic acid;3-Bromo-6-fluoropyridine-2-carboxylicacid
• CAS NO: 1211589-43-3
• Molecular Formula: C₆H₃BrFNO₂
• Molecular Weight: 220
• Mol File: 1211589-43-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 321.3±42.0 °C(Predicted)
• Appearance: /
• Density: 1.903±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.95±0.10(Predicted)
• CAS DataBase Reference: 3-Bromo-6-fluoropicolinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-6-fluoropicolinic acid(1211589-43-3)
• EPA Substance Registry System: 3-Bromo-6-fluoropicolinic acid(1211589-43-3)

Safety Data

• Hazardous Substances Data: 1211589-43-3(Hazardous Substances Data)

Usage

General Description

3-Bromo-6-fluoropicolinic acid is a chemical compound with the molecular formula C6H3BrFNO2. It is a derivative of picolinic acid and belongs to the class of halogenated acids. 3-Bromo-6-fluoropicolinic acid is used in the field of organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active compounds. Its properties and structure make it an important intermediate in the development of new drugs and agrochemicals. Additionally, 3-Bromo-6-fluoropicolinic acid has potential applications in the field of material science and catalysis due to its unique chemical reactivity and properties.

Upstream product

• 375368-83-5 3-bromo-6-fluoro-2-methyl-pyridine 
• 42753-71-9 5-bromo-6-methyl-pyridin-2-ylamine 
• 1033201-61-4 6-amino-3-bromopicolinic acid 

Downstream Products

• 1227502-92-2 3-bromo-6-fluoro-2-(trifluoromethyl)pyridine 

Relevant articles and documents

ANTI-EGFR ANTIBODY DRUG CONJUGATES

The invention relates to anti-Epidermal Growth Factor Receptor (EGFR) antibody drug conjugates (ADCs) which inhibit Bcl-xL, including compositions and methods of using said ADCs.

Synthesis method of 3-bromo-6-fluoro-2-pyridinone

The invention provides a synthesis method of 3-bromo-6-fluoro-2-pyridinone. The synthesis method comprises the following steps: 1) dissolving 3-bromo-6-fluoro-2-picolinic acid in a solvent, and addingpotassium permanganate to obtain 3-bromo-6-fluoro-2-picolinic acid; 2) adding thionyl chloride to 3-bromo-6-fluoro-2-picolinic acid, adding a mixture of triethylamine, dichloromethane and N,O-dimethylhydroxylamine hydrochloride to obtain 3-bromo-6-fluoro-N-methoxy-N-methyl picolinamide; 3) adding tetrahydrofuran to 3-bromo-6-fluoro-N-methoxy-N-methyl picolinamide and methylmagnesium chloride forreaction to obtain 3-bromo-6-fluoro-2-pyridinone. The synthesis method has the advantages of simple synthesis route, reasonable process selection and cheap, simple and available raw materials, operation and aftertreatment are convenient, expansion is facilitated, and large-scale production of 3-bromo-6-fluoro-2-pyridinone can be performed.

ANTI-EGFR ANTIBODY DRUG CONJUGATES

The invention relates to anti-Epidermal Growth Factor Receptor (EGFR) antibody drug conjugates (ADCs) which inhibit Bcl-xL, including compositions and methods of using said ADCs.