Benzoic acid, 2-fluoro-5-(Methylsulfonyl)-, Methyl ester

Base Information

• Chemical Name: Benzoic acid, 2-fluoro-5-(Methylsulfonyl)-, Methyl ester
• CAS No.: 865663-98-5
• Molecular Formula: C9H9FO4S
• Molecular Weight: 232.232
• Mol file: 865663-98-5.mol

Synonyms:Benzoic acid, 2-fluoro-5-(Methylsulfonyl)-, Methyl ester;methyl 2-fluoro-5-(methylsulfonyl)benzoate

Chemical Property of Benzoic acid, 2-fluoro-5-(Methylsulfonyl)-, Methyl ester

Chemical Property:

• PSA: 68.82000
• LogP: 2.09660

Purity/Quality:

≥95% ^*data from raw suppliers

2-Fluoro-5-methanesulfonyl-benzoicacidmethylester 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 2-fluoro-5-(Methylsulfonyl)-, Methyl ester

There total 3 articles about Benzoic acid, 2-fluoro-5-(Methylsulfonyl)-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

2-fluoro-5-sulfinobenzoic acid (1229627-84-2) + methyl iodide (74-88-4) → 2-fluoro-5-methanesulfonylbenzoic acid methyl ester (865663-98-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm100210p

Reference yield:

2-fluoro-5-chlorosulfonylbenzoic acid (37098-75-2) + methyl iodide (74-88-4) → 2-fluoro-5-methanesulfonylbenzoic acid methyl ester (865663-98-5)

Guidance literature:

2-fluoro-5-chlorosulfonylbenzoic acid; With sodium sulfite; In water; at 20 ℃; for 2h;

methyl iodide; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

2-fluoro-5-chlorosulfonylbenzoic acid (37098-75-2) → 2-fluoro-5-methanesulfonylbenzoic acid methyl ester (865663-98-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium sulfite / water / 2 h / 20 °C

1.2: 0 °C / pH 2

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With potassium carbonate; sodium sulfite; In water; N,N-dimethyl-formamide;

upstream raw materials:

2-fluoro-5-sulfinobenzoic acid

methyl iodide

2-fluoro-5-chlorosulfonylbenzoic acid

Downstream raw materials:

2-fluoro-5-(methylsulfonyl)benzoic acid

methyl 5-(methylsulfonyl)-2-(1-piperidinyl)benzoate

5-methanesulfonyl-2-piperidin-1-yl-benzoic acid

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