2-Bromo-5-(4-fluorophenyl)thiophene

Base Information

• Chemical Name: 2-Bromo-5-(4-fluorophenyl)thiophene
• CAS No.: 1073313-97-9
• Molecular Formula: C10H6BrFS
• Molecular Weight: 257.126
• DSSTox Substance ID: DTXSID50697085
• Wikidata: Q72456437
• Mol file: 1073313-97-9.mol

Synonyms:2-BROMO-5-(4-FLUOROPHENYL)THIOPHENE;1073313-97-9;SCHEMBL1995968;DTXSID50697085;SVSGIDPCBJSBSB-UHFFFAOYSA-N;MFCD18782089;CS-0499013;FT-0755059

Chemical Property of 2-Bromo-5-(4-fluorophenyl)thiophene

Chemical Property:

• Boiling Point: 287℃
• Flash Point: 127℃
• PSA: 28.24000
• Density: 1.562
• LogP: 4.31670
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 255.93576
• Heavy Atom Count: 13
• Complexity: 168

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-5-(4-fluorophenyl)thiophene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=CC=C(S2)Br)F

Technology Process of 2-Bromo-5-(4-fluorophenyl)thiophene

There total 5 articles about 2-Bromo-5-(4-fluorophenyl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.3%

2-(4-fluorophenyl)thiophene (58861-48-6) → 2-bromo-5-(4-fluorophenyl)thiophene (1073313-97-9)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane;

Reference yield: 91.0%

2-bromothiophene (1003-09-4) + (p-fluorophenyl)trimethylsilane (455-17-4) → 2-bromo-5-(4-fluorophenyl)thiophene (1073313-97-9)

Guidance literature:

With (Ph₃P)Au^(I)(OTs); [bis(acetoxy)iodo]benzene; camphor-10-sulfonic acid; In methanol; chloroform; at 20 ℃;

DOI:10.1126/science.1225709

Reference yield: 82.0%

4-fluoro-1-iodobenzene (352-34-1) + (5-bromothiophen-2-yl)tributylstannane (143724-36-1) → 2-bromo-5-(4-fluorophenyl)thiophene (1073313-97-9)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 60 ℃;

upstream raw materials:

4-fluoro-1-iodobenzene

(5-bromothiophen-2-yl)tributylstannane

2-bromothiophene

(p-fluorophenyl)trimethylsilane

Downstream raw materials:

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

3-bromo-5-(4-fluorophenyl)thiophene-2-carbaldehyde

Refernces

• 1、 -. "Deuterium-modified carbon glycoside derivate". Paragraph 0089; 0090; 0091; 0092; 0093; 0094. . Retrieved 2016/12/26.
• 2、 Minard, Corinne,Palacio, Carole,Cariou, Kevin,Dodd, Robert H.. "Selective Suzuki-Miyaura monocouplings with symmetrical dibromoarenes and aryl ditriflates for the one-pot synthesis of unsymmetrical triaryls". . p. 2942 - 2955. Retrieved 2014/05/20.