cis-3-Methyl-4-(phenylaMino)-1-(phenylMethyl)-4-piperidinecarboxaMide

Base Information

• Chemical Name: cis-3-Methyl-4-(phenylaMino)-1-(phenylMethyl)-4-piperidinecarboxaMide
• CAS No.: 147292-26-0
• Molecular Formula: C₂₀H₂₅N₃O
• Molecular Weight: 323.438
• Mol file: 147292-26-0.mol

Synonyms:cis-3-Methyl-4-(phenylaMino)-1-(phenylMethyl)-4-piperidinecarboxaMide

Chemical Property of cis-3-Methyl-4-(phenylaMino)-1-(phenylMethyl)-4-piperidinecarboxaMide

Chemical Property:

• Boiling Point: 524.9±50.0 °C(Predicted)
• PKA: 15.38±0.40(Predicted)
• Density: 1.165±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

cis-3-Methyl-4-(phenylamino)-1-(phenylmethyl)-4-piperidinecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Intermediate in the preparation of fentanyl and its analogs.

Technology Process of cis-3-Methyl-4-(phenylaMino)-1-(phenylMethyl)-4-piperidinecarboxaMide

There total 6 articles about cis-3-Methyl-4-(phenylaMino)-1-(phenylMethyl)-4-piperidinecarboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(+/-)-1-benzyl-t-4-cyano-r-3-methyl-N-phenyl-4-piperidinamine (147292-25-9,147292-24-8) → (+/-)-1-benzyl-r-3-methyl-c-4-(N-phenyl)aminoisonipecotamide (147292-26-0)

Guidance literature:

With sulfuric acid; for 48h; Ambient temperature;

DOI:10.1002/jhet.5570310243

Reference yield: 68.0%

(+/-)-1-benzyl-c-4-cyano-r-3-methyl-N-phenyl-4-piperidinamine (147292-25-9,147292-24-8) → (+/-)-1-benzyl-r-3-methyl-t-4-(N-phenyl)aminoisonipecotamide (147292-26-0)

Guidance literature:

With sulfuric acid; for 48h; Ambient temperature;

DOI:10.1002/jhet.5570310243

Reference yield:

1-Benzyl-3-methyl-4-piperidon (34737-89-8) → (+/-)-1-benzyl-r-3-methyl-c-4-(N-phenyl)aminoisonipecotamide (147292-26-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) gl. AcOH / 2.) H₂O, RT, 45 min

2: 76 percent / conc. H₂SO₄ / 48 h / Ambient temperature

With sulfuric acid; acetic acid;

DOI:10.1002/jhet.5570310243

upstream raw materials:

(+/-)-1-benzyl-t-4-cyano-r-3-methyl-N-phenyl-4-piperidinamine

1-Benzyl-3-methyl-4-piperidon

aniline

(+/-)-1-benzyl-c-4-cyano-r-3-methyl-N-phenyl-4-piperidinamine

Refernces