trans-(+)-3-Methyl-4-(phenylaMino)-1-(phenylMethyl)-4-piperidinecarbonitrile

Base Information

• Chemical Name: trans-(+)-3-Methyl-4-(phenylaMino)-1-(phenylMethyl)-4-piperidinecarbonitrile
• CAS No.: 147292-25-9
• Molecular Formula: C₂₀H₂₃N₃
• Molecular Weight: 305.423
• Mol file: 147292-25-9.mol

Synonyms:trans-(+)-3-Methyl-4-(phenylaMino)-1-(phenylMethyl)-4-piperidinecarbonitrile;trans-3-Methyl-4-(phenylaMino)-1-(phenylMethyl)-4-piperidinecarbonitrile

Chemical Property of trans-(+)-3-Methyl-4-(phenylaMino)-1-(phenylMethyl)-4-piperidinecarbonitrile

Chemical Property:

• Boiling Point: 475.6±45.0 °C(Predicted)
• PKA: 6.36±0.10(Predicted)
• Density: 1.12±0.1 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

trans-3-Methyl-4-(phenylamino)-1-(phenylmethyl)-4-piperidinecarbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Intermediate in the preparation of fentanyl and its analogs.

Technology Process of trans-(+)-3-Methyl-4-(phenylaMino)-1-(phenylMethyl)-4-piperidinecarbonitrile

There total 4 articles about trans-(+)-3-Methyl-4-(phenylaMino)-1-(phenylMethyl)-4-piperidinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Benzyl-3-methyl-4-piperidon (34737-89-8) + trimethylsilyl cyanide (7677-24-9) + aniline (62-53-3) → (+/-)-1-benzyl-t-4-cyano-r-3-methyl-N-phenyl-4-piperidinamine (147292-25-9,147292-24-8) + (+/-)-1-benzyl-c-4-cyano-r-3-methyl-N-phenyl-4-piperidinamine (147292-25-9,147292-24-8)

Guidance literature:

With acetic acid; Multistep reaction; 2.) H₂O, RT, 45 min;

DOI:10.1002/jhet.5570310243

Reference yield:

1-Benzyl-3-methyl-4-piperidon (34737-89-8) + trimethylsilyl cyanide (7677-24-9) + aniline (62-53-3) → (+/-)-1-benzyl-t-4-cyano-r-3-methyl-N-phenyl-4-piperidinamine (147292-25-9,147292-24-8) + (+/-)-1-benzyl-c-4-cyano-r-3-methyl-N-phenyl-4-piperidinamine (147292-25-9,147292-24-8)

Guidance literature:

With acetic acid; Multistep reaction; 2.) H₂O, RT, 45 min;

DOI:10.1002/jhet.5570310243

Reference yield:

1-Benzyl-3-methyl-4-piperidon (34737-89-8) + potassium cyanide (151-50-8) + aniline (62-53-3) → (+/-)-1-benzyl-t-4-cyano-r-3-methyl-N-phenyl-4-piperidinamine (147292-25-9,147292-24-8) + (+/-)-1-benzyl-c-4-cyano-r-3-methyl-N-phenyl-4-piperidinamine (147292-25-9,147292-24-8)

Guidance literature:

With acetic acid; Yield given. Multistep reaction. Yields of byproduct given; 2.) H₂O, RT, 2 days;

DOI:10.1002/jhet.5570310243

upstream raw materials:

1-Benzyl-3-methyl-4-piperidon

trimethylsilyl cyanide

aniline

potassium cyanide

Refernces