4-chloro-2-fluorophenylboronic aicd, pinacol ester

Base Information

• Chemical Name: 4-chloro-2-fluorophenylboronic aicd, pinacol ester
• CAS No.: 765917-27-9
• Molecular Formula: C12H15BClFO2
• Molecular Weight: 274.5239832
• Hs Code.: 2934999090
• Mol file: 765917-27-9.mol

Synonyms:4-chloro-2-fluorophenylboronic aicd, pinacol ester;2-(4-Chloro-2-fluorophenyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane;4-Chloro-2-fluorobenzeneboronic acid pinacol ester, 96%

Chemical Property of 4-chloro-2-fluorophenylboronic aicd, pinacol ester

Chemical Property:

• PSA: 18.46000
• LogP: 2.77830
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

4-chloro-2-fluorophenylboronicaicd,pinacolester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-chloro-2-fluorophenylboronic aicd, pinacol ester

There total 7 articles about 4-chloro-2-fluorophenylboronic aicd, pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (61676-62-8) + 3-chlorofluorobenzene (625-98-9) → 2-(4-chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (765917-27-9) + 2-(2-chloro-6-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1599432-38-8)

Guidance literature:

3-chlorofluorobenzene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; diisopropylamine; In tetrahydrofuran; at -78 ℃; for 1.66667h; Inert atmosphere;

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; at -78 - 0 ℃;

DOI:10.1071/CH13642

Reference yield: 45.0%

3-chlorofluorobenzene (625-98-9) + bis(pinacol)diborane (73183-34-3) → 2-(4-chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (765917-27-9) + 2-(2-chloro-6-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1599432-38-8)

Guidance literature:

3-chlorofluorobenzene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; diisopropylamine; In tetrahydrofuran; at -78 ℃; for 1.66667h; Inert atmosphere;

bis(pinacol)diborane; at -78 - 0 ℃;

DOI:10.1071/CH13642

Reference yield:

2,3-dimethyl-2,3-butane diol (76-09-5) + C6H3BCl3F → 2-(4-chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (765917-27-9)

Guidance literature:

With triethylamine; In dimethylsulfoxide-d6; dichloromethane; at 0 - 20 ℃; for 14h; Inert atmosphere;

DOI:10.1039/c4cc10153g

upstream raw materials:

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

3-chlorofluorobenzene

bis(pinacol)diborane

2,3-dimethyl-2,3-butane diol

Downstream raw materials:

3-(4-chloro-2-fluorophenyl)-5-[4-fluoro-3-(3-fluoropyridin-2-yl)phenyl]-[1,2,4]triazine

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