2-(2-chloro-6-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Base Information

• Chemical Name: 2-(2-chloro-6-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS No.: 1599432-38-8
• Molecular Formula: C₁₂H₁₅BClFO₂
• Molecular Weight: 256.512
• Hs Code.: 2931900090

Synonyms:2-(2-chloro-6-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property of 2-(2-chloro-6-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property:

• Boiling Point: 312.6±32.0 °C(Predicted)
• Density: 1.16±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

2-(2-Chloro-6-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane ^*data from reagent suppliers

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Technology Process of 2-(2-chloro-6-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

There total 4 articles about 2-(2-chloro-6-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (61676-62-8) + 3-chlorofluorobenzene (625-98-9) → 2-(4-chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (765917-27-9) + 2-(2-chloro-6-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1599432-38-8)

Guidance literature:

3-chlorofluorobenzene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; diisopropylamine; In tetrahydrofuran; at -78 ℃; for 1.66667h; Inert atmosphere;

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; at -78 - 0 ℃;

DOI:10.1071/CH13642

Reference yield: 45.0%

3-chlorofluorobenzene (625-98-9) + bis(pinacol)diborane (73183-34-3) → 2-(4-chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (765917-27-9) + 2-(2-chloro-6-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1599432-38-8)

Guidance literature:

3-chlorofluorobenzene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; diisopropylamine; In tetrahydrofuran; at -78 ℃; for 1.66667h; Inert atmosphere;

bis(pinacol)diborane; at -78 - 0 ℃;

DOI:10.1071/CH13642

Reference yield:

2,3-dimethyl-2,3-butane diol (76-09-5) + (2-chloro-6-fluorophenyl)boronic acid (313545-32-3) → 2-(2-chloro-6-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1599432-38-8)

Guidance literature:

In toluene; at 110 ℃;

upstream raw materials:

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

3-chlorofluorobenzene

bis(pinacol)diborane

2,3-dimethyl-2,3-butane diol

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