[1-(Hydroxymethyl)-3,3-dimethoxycyclobutyl]methanol

Base Information

• Chemical Name: [1-(Hydroxymethyl)-3,3-dimethoxycyclobutyl]methanol
• CAS No.: 130369-33-4
• Molecular Formula: C₈H₁₆O₄
• Molecular Weight: 176.213
• European Community (EC) Number: 895-618-8
• Mol file: 130369-33-4.mol

Synonyms:130369-33-4;(3,3-dimethoxycyclobutane-1,1-diyl)dimethanol;[1-(hydroxymethyl)-3,3-dimethoxycyclobutyl]methanol;1,1-Cyclobutanedimethanol, 3,3-dimethoxy-;MFCD08436466;(1-Hydroxymethyl-3,3-dimethoxy-cycl;SCHEMBL871803;AMY5673;BCXOBYJPCUTNTN-UHFFFAOYSA-N;AKOS000319877;AS-76119;BP-11870;SY140193;CS-0069556;EN300-105992;3,3-Bis(hydroxymethyl)-1,1-dimethoxycyclobutane;3.3-Bis(hydroxymethyl)-1,1-dimethoxycyclobutane;A888761;F2124-1187;Z1198177284

Chemical Property of [1-(Hydroxymethyl)-3,3-dimethoxycyclobutyl]methanol

Chemical Property:

• XLogP3: -0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 176.10485899
• Heavy Atom Count: 12
• Complexity: 139

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1(CC(C1)(CO)CO)OC

Technology Process of [1-(Hydroxymethyl)-3,3-dimethoxycyclobutyl]methanol

There total 2 articles about [1-(Hydroxymethyl)-3,3-dimethoxycyclobutyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,3-dimethoxycyclobutane-1,1-dicarboxylic acid diisopropyl ester (115118-68-8) → (1-hydroxymethyl-3,3-dimethoxycyclobutyl)methanol (130369-33-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 12h;

Reference yield: 81.0%

diethyl 3,3-dimethoxycyclobutane-1,1-dicarboxylate (115118-67-7) → (1-hydroxymethyl-3,3-dimethoxycyclobutyl)methanol (130369-33-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; 1.) 2 h, 0 deg C 2.) 20 h, r.t.;

DOI:10.1002/jhet.5570270655

Reference yield: 88.0%

(1-hydroxymethyl-3,3-dimethoxycyclobutyl)methanol (130369-33-4) + p-toluenesulfonyl chloride (98-59-9) → (3,3-dimethoxycyclobutane-1,1-diyl)bis(methylene) bis(4-methylbenzenesulfonate) (1023815-74-8)

Guidance literature:

With pyridine; at 20 ℃; for 12h; Cooling with ice;

upstream raw materials:

diethyl 3,3-dimethoxycyclobutane-1,1-dicarboxylate

3,3-dimethoxycyclobutane-1,1-dicarboxylic acid diisopropyl ester

Downstream raw materials:

3,3-dimethoxy-1,1-bis(benzyloxymethyl)cyclobutane

3,3-bis-hydroxymethyl-cyclobutanone

C₁₇H₂₂O₃S₃

C₂₁H₂₄O₇S₂