115118-67-7

Upstream product

• 22094-18-4 1,3-dibromo-2,2-dimethoxypropane 
• 105-53-3 diethyl malonate 
• 153214-82-5 2,2-dimethoxypropane-1,3-diol 

Downstream Products

• 130369-33-4 (1-hydroxymethyl-3,3-dimethoxycyclobutyl)methanol 
• 23761-23-1 3-oxocyclobutanecarboxylic acid 
• 130368-81-9 9-<3,3-bis(hydroxymethyl)cyclobut-1-yl>guanine 
• 131853-47-9 9-<3,3-bis(hydroxymethyl)cyclobut-1-yl>adenine 
• 131853-56-0 9-<3,3-bis(benzyloxymethyl)cyclobut-1-yl>guanine 
• 131853-55-9 2-amino-6-chloro-9-<3,3-bis(benzyloxymethyl)cyclobut-1-yl>-9H-purine 
• 131853-53-7 2,5-diamino-6-chloro-4-<<3,3-bis(benzyloxymethyl)cyclobut-1-yl>amino>pyrimidine 
• 131853-57-1 9-<3,3-bis(benzyloxymethyl)cyclobut-1-yl>adenine 
• 131853-54-8 6-chloro-9-<3,3-bis(benzyloxymethyl)cyclobut-1-yl>-9H-purine 
• 131853-52-6 5-amino-6-chloro-4-<<3,3-bis(benzyloxymethyl)cyclobut-1-yl>amino>pyrimidine 
• 131853-58-2 9-<3-benzyloxymethyl-3-hydroxymethylcyclobut-1-yl>adenine 
• 131853-51-5 3,3-bis(benzyloxymethyl)cyclobutanone oxime 
• 131853-49-1 3,3-dimethoxy-1,1-bis(benzyloxymethyl)cyclobutane 
• 131853-50-4 3,3-bis(benzyloxymethyl)cyclobutanone 

Relevant academic research and scientific papers

Preparation method 3 - oxocyclobutane-based carboxylic acid

The invention discloses a preparation method of 3 -oxocyclobutane-based carboxylic acid, and belongs to the technical field of synthesis of medical intermediates. The ketone is protected from 1, 3 -dihydroxyacetone by condensation with trimethyl orthoformate to give 2, 2 -dimethoxy -1, 3 -propanediol, followed by reaction with malonate to give 3, 3 -dimethylcyclobutyl -1, 1 -dicarboxylic acid diester, followed by hydrolysis under acidic conditions. Decarboxylation and deprotection to yield 3 -oxocyclobutane-based carboxylic acids. The method has the advantages of high yield, common and easily available raw materials, simple flow and industrial amplification prospect.

Pyrazole glucokinase activators

Disclosed herein are pyrazole glucokinase activators of the formula (I) useful for the treatment of metabolic diseases and disorders, preferably diabetes mellitus.