2-HYDROXYQUINOLINE-6-CARBALDEHYDE

Base Information

• Chemical Name: 2-HYDROXYQUINOLINE-6-CARBALDEHYDE
• CAS No.: 90800-31-0
• Molecular Formula: C₁₀H₇NO₂
• Molecular Weight: 173.171
• Mol file: 90800-31-0.mol

Synonyms:2-HYDROXYQUINOLINE-6-CARBALDEHYDE;2-Hydroxy-6-quinolinecarboxaldehyde;2-Oxo-1,2-dihydro-6-quinolinecarboxaldehyde;1,2-dihydro-2-oxo-6-quinolinecarboxaldehyde

Chemical Property of 2-HYDROXYQUINOLINE-6-CARBALDEHYDE

Chemical Property:

• Melting Point: 284-285.5℃
• PSA: 50.19000
• LogP: 1.75290

Purity/Quality:

99% ^*data from raw suppliers

2-Hydroxyquinoline-6-carboxaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-HYDROXYQUINOLINE-6-CARBALDEHYDE

There total 5 articles about 2-HYDROXYQUINOLINE-6-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6-(1-hydroxy-2-isopropylaminopropyl)-2-(1H)-quinolinone (103702-41-6) → 2-oxo-1,2-dihydroquinoline-6-carbaldehyde (90800-31-0)

Guidance literature:

With sodium periodate; In water; N,N-dimethyl-formamide; at 60 - 70 ℃; for 2.5h;

DOI:10.1248/cpb.33.3775

Reference yield: 77.0%

→ 2-oxo-1,2-dihydroquinoline-6-carbaldehyde (90800-31-0)

Guidance literature:

Reference yield: 46.0%

2-chloro-6-(1,3-dioxolan-2-yl)quinoline (791626-62-5) → 2-oxo-1,2-dihydroquinoline-6-carbaldehyde (90800-31-0) + 6-(1,3-dioxolan-2-yl)quinolin-2(1H)-one + 6-[1,3]dioxolan-2-yl-quinolin-2-ylamine

Guidance literature:

With acetamide; potassium carbonate; at 200 ℃;

DOI:10.1021/jm049533z

upstream raw materials:

6-(1-hydroxy-2-isopropylaminopropyl)-2-(1H)-quinolinone

2-chloro-6-(1,3-dioxolan-2-yl)quinoline

2-chloro-6-methylquinoline

2-chloroquinoline-6-carbaldehyde

Downstream raw materials:

6-Bromomethyl-1H-quinolin-2-one

Refernces

• 1、 -. "NOVEL CHEMICAL COMPOUNDS". Page/Page column 43. . Retrieved 2010/11/25.
• 2、 Uchida,Tabusa,Komatsu,Morita,Kanbe,Nakagawa. "Studies on 2(1H)-quinolinone derivatives as gastric antiulcer active agents. 2-(4-Chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]propionic acid and related compounds". . p. 3775 - 3786. Retrieved 2007/10/02.