tert-butyl 4-((3-(2-(3-chlorobenzylamino)pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)methyl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-((3-(2-(3-chlorobenzylamino)pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)methyl)piperidine-1-carboxylate
• CAS No.: 1386399-59-2
• Molecular Formula: C₂₇H₃₂ClN₉O₂
• Molecular Weight: 550.063
• Mol file: 1386399-59-2.mol

Synonyms:tert-butyl 4-((3-(2-(3-chlorobenzylamino)pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)methyl)piperidine-1-carboxylate

Chemical Property of tert-butyl 4-((3-(2-(3-chlorobenzylamino)pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)methyl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-((3-(2-(3-chlorobenzylamino)pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)methyl)piperidine-1-carboxylate

There total 7 articles about tert-butyl 4-((3-(2-(3-chlorobenzylamino)pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.2%

4-{[3-(2-methanesulfinyl-pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester (1386398-92-0) + m-chlorobenzylamine (4152-90-3) → 4-({3-[2-(3-chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino}-methyl)-piperidine-1-carboxylic acid tert-butyl ester (1386399-59-2)

Guidance literature:

at 130 ℃; for 2h;

Reference yield:

6-chloro-3-(2-methylsulfanyl-pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine (1386398-83-9) → 4-({3-[2-(3-chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino}-methyl)-piperidine-1-carboxylic acid tert-butyl ester (1386399-59-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / isopropyl alcohol / 15 h / Reflux

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane; methanol / 0.33 h / 20 °C

3: 2 h / 130 °C

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; isopropyl alcohol;

Reference yield:

4-formyl-2-(methylthio)pyrimidine (1074-68-6) → 4-({3-[2-(3-chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino}-methyl)-piperidine-1-carboxylic acid tert-butyl ester (1386399-59-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -30 °C

1.2: 1 h / 0 °C

2.1: manganese(IV) oxide / dichloromethane; methanol / 16 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine; hydrazine hydrate / tetrahydrofuran / 4 h / 50 °C

4.1: triethylamine / isopropyl alcohol / 15 h / Reflux

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; methanol / 0.33 h / 20 °C

6.1: 2 h / 130 °C

With manganese(IV) oxide; isopropylmagnesium chloride; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;

upstream raw materials:

4-{[3-(2-methanesulfinyl-pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester

m-chlorobenzylamine

4-formyl-2-(methylthio)pyrimidine

6-chloro-3-(2-methylsulfanyl-pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine

Downstream raw materials:

{3-[2-(3-chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-piperidin-4-ylmethyl-amine hydrochloride