{3-[2-(3-chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-piperidin-4-ylmethyl-amine hydrochloride

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Chemical Name:{3-[2-(3-chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-piperidin-4-ylmethyl-amine hydrochloride
CAS No.:1386398-67-9
Molecular Formula:C₂₂H₂₄ClN₉*ClH
Molecular Weight:486.407
Hs Code.:

Synonyms:{3-[2-(3-chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-piperidin-4-ylmethyl-amine hydrochloride

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Chemical Property of {3-[2-(3-chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-piperidin-4-ylmethyl-amine hydrochloride

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Technology Process of {3-[2-(3-chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-piperidin-4-ylmethyl-amine hydrochloride

There total 7 articles about {3-[2-(3-chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-piperidin-4-ylmethyl-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1386399-59-2
4-({3-[2-(3-chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino}-methyl)-piperidine-1-carboxylic acid tert-butyl ester

: 1386398-67-9
{3-[2-(3-chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-piperidin-4-ylmethyl-amine hydrochloride

Guidance literature:: With hydrogenchloride; water; In ethanol; at 20 ℃; for 15h;

Reference yield:

: 1386398-83-9
6-chloro-3-(2-methylsulfanyl-pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine

: 1386398-67-9
{3-[2-(3-chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-piperidin-4-ylmethyl-amine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / isopropyl alcohol / 15 h / Reflux

2: 3-chloro-benzenecarboperoxoic acid / methanol; dichloromethane / 0.33 h / 20 °C

3: 2 h / 130 °C

4: hydrogenchloride; water / ethanol / 15 h / 20 °C

With hydrogenchloride; water; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; ethanol; dichloromethane; isopropyl alcohol;

Reference yield:

: 1386398-84-0
(2,4-dichloro-pyrimidin-5-yl)-(2-methylsulfanyl-pyrimidin-4-yl)-methanol

: 1386398-67-9
{3-[2-(3-chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-piperidin-4-ylmethyl-amine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: manganese(IV) oxide / methanol; dichloromethane / 16 h / Reflux

2: hydrazine hydrate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 50 °C

3: triethylamine / isopropyl alcohol / 15 h / Reflux

4: 3-chloro-benzenecarboperoxoic acid / methanol; dichloromethane / 0.33 h / 20 °C

5: 2 h / 130 °C

6: hydrogenchloride; water / ethanol / 15 h / 20 °C

With hydrogenchloride; manganese(IV) oxide; water; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; isopropyl alcohol;