4'-[(tert-Butyldimethylsilyloxy)methyl]-2,2,2-trifluoroacetophenone

Base Information

Chemical Name:4'-[(tert-Butyldimethylsilyloxy)methyl]-2,2,2-trifluoroacetophenone
CAS No.:87736-75-2
Molecular Formula:C15H21F3O2Si
Molecular Weight:318.411
Hs Code.:
DSSTox Substance ID:DTXSID40516857
Wikidata:Q82378490
Mol file:87736-75-2.mol

Synonyms:87736-75-2;4'-[(tert-Butyldimethylsilyloxy)methyl]-2,2,2-trifluoroacetophenone;O-tert-Butyldimethylsilyl-benzyl Alcohol 4-(2,2,2-Trifluoroethanone);1-[4-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]phenyl]-2,2,2-trifluoro-ethanone;1-[4-[[tert-butyl(dimethyl)silyl]oxymethyl]phenyl]-2,2,2-trifluoroethanone;SCHEMBL992588;DTXSID40516857;MFCD29089349;B5156;FT-0664129;T71424;[(4-(Trifluoroacetyl)benzyl)oxy](tert-butyl)dimethylsilane;1-(4-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,2-trifluoroethanone;1-(4-((tert.-butyldimethylsilyloxy)methyl)phenyl)-2,2,2-trifluoroethanone;1-[4-({[tert-Butyl(dimethyl)silyl]oxy}methyl)phenyl]-2,2,2-trifluoroethan-1-one

Suppliers and Price of 4'-[(tert-Butyldimethylsilyloxy)methyl]-2,2,2-trifluoroacetophenone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
O-tert-Butyldimethylsilyl-benzylAlcohol4-(2,2,2-Trifluoroethanone)
500mg
$ 1230.00

TRC
O-tert-Butyldimethylsilyl-benzylAlcohol4-(2,2,2-Trifluoroethanone)
50mg
$ 155.00

TCI Chemical
4'-[(tert-Butyldimethylsilyloxy)methyl]-2,2,2-trifluoroacetophenone >97.0%(GC)
5g
$ 316.00

Medical Isotopes, Inc.
O-tert-Butyldimethylsilyl-benzylAlcohol4-(2,2,2-Trifluoroethanone)
50 mg
$ 640.00

AK Scientific
4'-[(Tert-Butyldimethylsilyloxy)methyl]-2,2,2-trifluoroacetophenone
5g
$ 471.00

Total 6 raw suppliers

Chemical Property of 4'-[(tert-Butyldimethylsilyloxy)methyl]-2,2,2-trifluoroacetophenone

Chemical Property:

Refractive Index:1.4660 to 1.4700
Boiling Point:145°C/0.8mmHg(lit.)
PSA：26.30000
LogP:4.95340
Storage Temp.:Refrigerator
Solubility.:Dichloromethane, Diethyl Ether, Ethyl Acetate, Methanol
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:318.12629093
Heavy Atom Count:21
Complexity:364

Purity/Quality:

97% ^*data from raw suppliers

O-tert-Butyldimethylsilyl-benzylAlcohol4-(2,2,2-Trifluoroethanone) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)[Si](C)(C)OCC1=CC=C(C=C1)C(=O)C(F)(F)F
Uses 1-[4-[[[(1,1-DiMethylethyl)diMethylsilyl]oxy]Methyl]phenyl]-2,2,2-trifluoro-ethanone can be used as an intermediate in the preparation of trifluoromethyldiazirine, useful as a photo-induced cross-linking probe for exploring amyloid formation.

Technology Process of 4'-[(tert-Butyldimethylsilyloxy)methyl]-2,2,2-trifluoroacetophenone

There total 7 articles about 4'-[(tert-Butyldimethylsilyloxy)methyl]-2,2,2-trifluoroacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 383-63-1
ethyl trifluoroacetate,

: 147283-96-3
4-(tert-butyldimethylsiloxymethyl)iodobenzene

: 87736-75-2
1-<4-<(tert-butyldimethylsilyloxy)methyl>phenyl>-2,2,2-trifluoro-1-ethanone

Guidance literature:: 4-(tert-butyldimethylsiloxymethyl)iodobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.75h;

ethyl trifluoroacetate,; In tetrahydrofuran; hexane; at -78 ℃; for 1.25h;
DOI:10.1021/jo402738t

Reference yield: 93.0%

: 360-92-9
N,N-diethyl-2,2,2-trifluoroacetamide

: 87736-74-1
4-(tert-butyldimethylsiloxymethyl)bromobenzene

: 87736-75-2
1-<4-<(tert-butyldimethylsilyloxy)methyl>phenyl>-2,2,2-trifluoro-1-ethanone

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -74 ℃; for 1.25h;
DOI:10.1016/S0040-4039(00)60743-8

Reference yield: 89.0%

: 340-07-8
N-(trifluoroacetyl)piperidine

: 87736-74-1
4-(tert-butyldimethylsiloxymethyl)bromobenzene

: 87736-75-2
1-<4-<(tert-butyldimethylsilyloxy)methyl>phenyl>-2,2,2-trifluoro-1-ethanone

Guidance literature:: 4-(tert-butyldimethylsiloxymethyl)bromobenzene; With n-butyllithium; In tetrahydrofuran; at -30 ℃;

N-(trifluoroacetyl)piperidine; In tetrahydrofuran; at -50 ℃;
DOI:10.1002/ejoc.200600449