N-Methyl-N-phenyltrifluoroacetamide

Base Information

• Chemical Name: N-Methyl-N-phenyltrifluoroacetamide
• CAS No.: 345-81-3
• Molecular Formula: C9H8F3NO
• Molecular Weight: 203.164
• Hs Code.: 2924299090
• Mol file: 345-81-3.mol

Synonyms:2,2,2-Trifluoro-N-methyl-N-phenylacetamide;N-Methyl-N-phenyltrifluoroacetamide

Chemical Property of N-Methyl-N-phenyltrifluoroacetamide

Chemical Property:

• PSA: 20.31000
• LogP: 2.21170

Purity/Quality:

98%min ^*data from raw suppliers

2,2,2-TRIFLUORO-N-METHYL-N-PHENYLACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Methyl-N-phenyltrifluoroacetamide

There total 11 articles about N-Methyl-N-phenyltrifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-methylaniline (100-61-8) + trifluoroacetic acid (76-05-1) → 2,2,2-Trifluoro-N-methyl-N-phenyl-acetamide (345-81-3)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1002/anie.201809929

Reference yield: 70.0%

sodium 2,2,2-trifluoroacetate (2923-18-4) + N-methylaniline (100-61-8) → 2,2,2-Trifluoro-N-methyl-N-phenyl-acetamide (345-81-3)

Guidance literature:

With iodine; triethylamine; triphenylphosphine; In dichloromethane; at 20 ℃; for 1.5h;

DOI:10.1080/00397910008086929

Reference yield: 44.0%

trifluoroacetic acid-methyl ester (431-47-0) + 2,2,2-trifluoro-N-phenylacetamide (404-24-0) → 2,2,2-Trifluoro-N-methyl-N-phenyl-acetamide (345-81-3)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 60 ℃; for 10h;

upstream raw materials:

N-methylaniline

trifluoroacetic anhydride

2,2,2-trifluoro-N-phenylacetamide

methyl iodide

Downstream raw materials:

N-(2,2,2-trifluoro-1-methoxyethyl)-N-methylaniline

N-(2,2,2-trifluoroethyl)-aniline

ethyl trifluoroacetate,

N-methylaniline

Refernces

• 1、 Rocaboy, Ronan,Dailler, David,Zellweger, Florian,Neuburger, Markus,Salomé, Christophe,Clot, Eric,Baudoin, Olivier. "Domino Pd0-Catalyzed C(sp3)–H Arylation/Electrocyclic Reactions via Benzazetidine Intermediates". . p. 12131 - 12135. Retrieved 2018/09/11.
• 2、 Zhou, Qi-Zhong,Chen, Zhen-Chu. "A convenient synthesis of Trifluoroacetamides from sodium trifluoroacetate and amines". . p. 3189 - 3194. Retrieved 2007/10/03.