1-METHOXY-3-METHYL-2-BUTANAMINE HYDROCHLORIDE

Base Information

• Chemical Name: 1-METHOXY-3-METHYL-2-BUTANAMINE HYDROCHLORIDE
• CAS No.: 1185294-54-5
• Molecular Formula: C6H16ClNO
• Molecular Weight: 153.65034
• Hs Code.: 2922199090
• Mol file: 1185294-54-5.mol

Synonyms:1-METHOXY-3-METHYL-2-BUTANAMINE HYDROCHLORIDE

Chemical Property of 1-METHOXY-3-METHYL-2-BUTANAMINE HYDROCHLORIDE

Chemical Property:

• PSA: 35.25000
• LogP: 2.11840

Purity/Quality:

98%min ^*data from raw suppliers

1-Methoxy-3-methyl-2-butanamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-METHOXY-3-METHYL-2-BUTANAMINE HYDROCHLORIDE

There total 1 articles about 1-METHOXY-3-METHYL-2-BUTANAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

ethylmagnesium bromide (925-90-6) + N-[(1S)-1-(methoxymethyl)-2-methylpropyl]benzamide (87768-46-5) → 1-phenyl-propan-1-one (93-55-0) + 1-(1-methylethoxy)-3-phenyl-2-propylamine hydrochloride (1185294-54-5)

Guidance literature:

N-[(1S)-1-(methoxymethyl)-2-methylpropyl]benzamide; With 2-fluoropyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at 0 ℃; for 0.5h;

ethylmagnesium bromide; With cerium(III) chloride; In tetrahydrofuran; dichloromethane; at -78 ℃; for 2h;

With hydrogenchloride; In ethyl acetate;

DOI:10.1016/j.cclet.2015.05.033

Reference yield:

(R)-1-methoxymethyl-2-methyl-propylamine hydrochloride (175458-86-3,1185294-54-5) → 4-hydroxy-7-[1R-hydroxy-2-(2-{3-[(1R-methoxymethyl-2-methyl-propylamino)-methyl]-phenyl}-ethylamino)-ethyl]-3H-benzothiazol-2-one dihydrochloride

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium tris(acetoxy)borohydride / 1-methyl-pyrrolidin-2-one; dichloromethane / 4 h / 20 °C

2.1: dichloromethane / 18 h / 20 °C

3.1: water; acetic acid / tetrahydrofuran / 4.5 h / Heating / reflux

4.1: Dess-Martin periodane / dichloromethane / 1 h

5.1: hydrogenchloride; sodium cyanoborohydride; acetic acid / methanol; diethyl ether / 2.5 h / 0 - 20 °C

6.1: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C

6.2: 0.08 h / 20 °C

With hydrogenchloride; water; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; Dess-Martin periodane; acetic acid; trifluoroacetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; dichloromethane;

Reference yield:

(R)-1-methoxymethyl-2-methyl-propylamine hydrochloride (175458-86-3,1185294-54-5) → (1R-methoxymethyl-2-methyl-propyl)-[3-(2-oxo-ethyl)-benzyl]-carbamic acid tert-butyl ester (950504-35-5)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium tris(acetoxy)borohydride / 1-methyl-pyrrolidin-2-one; dichloromethane / 4 h / 20 °C

2: dichloromethane / 18 h / 20 °C

3: water; acetic acid / tetrahydrofuran / 4.5 h / Heating / reflux

4: Dess-Martin periodane / dichloromethane / 1 h

With water; sodium tris(acetoxy)borohydride; Dess-Martin periodane; acetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane;

upstream raw materials:

ethylmagnesium bromide

N-[(1S)-1-(methoxymethyl)-2-methylpropyl]benzamide

Downstream raw materials:

(1R-methoxymethyl-2-methyl-propyl)-[3-(2-oxo-ethyl)-benzyl]-carbamic acid tert-butyl ester

[3-(2-hydroxy-ethyl)-benzyl]-(1R-methoxymethyl-2-methyl-propyl)-carbamic acid tert-butyl ester

(3-{2R-[2-hydroxy-2-(4-hydroxy-2-oxo-2,3-dihydro-benzothiazol-7-yl)-ethylamino]-ethyl}-benzyl)-(1R-methoxymethyl-2-methyl-propyl)-carbamic acid tert-butyl ester

Refernces