Methyl 1-Cbz-3-Methylazet...

Base Information

• Chemical Name: Methyl 1-Cbz-3-Methylazet...
• CAS No.: 912444-78-1
• Molecular Formula: C13H15NO2
• Molecular Weight: 263.293
• Hs Code.: 2933990090
• Mol file: 912444-78-1.mol

Synonyms:Methyl 1-Cbz-3-Methylazet...;Methyl 1-Cbz-3-Methylazetidine-3-carboxylate;1-benzyl 3-methyl 3-methylazetidine-1,3-dicarboxylate

Chemical Property of Methyl 1-Cbz-3-Methylazet...

Chemical Property:

• PSA: 55.84000
• LogP: 1.75600

Purity/Quality:

97% ^*data from raw suppliers

Methyl1-CBZ-3-methylazetidine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 1-Cbz-3-Methylazet...

There total 3 articles about Methyl 1-Cbz-3-Methylazet... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(Benzyloxycarbonyloxy)succinimide (13139-17-8) + methyl 3-methylazetidine-3-carboxylate hydrochloride (1114876-08-2) → 1-benzyl 3-methyl 3-methylazetidine-1,3-dicarboxylate (912444-78-1)

Guidance literature:

With triethylamine; In dichloromethane; at 25 ℃; for 1h; Inert atmosphere;

Reference yield: 85.0%

O1-benzyl-O3-methylazetidine-1,3-dicarboxylate (757239-60-4) + methyl iodide (74-88-4) → 1-benzyl 3-methyl 3-methylazetidine-1,3-dicarboxylate (912444-78-1)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at -70 - -20 ℃; for 3h;

Reference yield:

3-methyl-azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester (898228-37-0) → 1-benzyl 3-methyl 3-methylazetidine-1,3-dicarboxylate (912444-78-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; water / 1 h / 15 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1 h / 25 °C / Inert atmosphere

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane; water;

upstream raw materials:

O₁-benzyl-O₃-methylazetidine-1,3-dicarboxylate

methyl iodide

N-(Benzyloxycarbonyloxy)succinimide

methyl 3-methylazetidine-3-carboxylate hydrochloride

Downstream raw materials:

1-((benzyloxy)carbonyl)-3-methylazetidine-3-carboxylic acid