Methyl 1-Boc-3-methylazetidine-3-carboxylate

Base Information

• Chemical Name: Methyl 1-Boc-3-methylazetidine-3-carboxylate
• CAS No.: 898228-37-0
• Molecular Formula: C11H19NO4
• Molecular Weight: 229.27286
• Hs Code.: 2933998090
• Mol file: 898228-37-0.mol

Synonyms:Methyl 1-Boc-3-methylazetidine-3-carboxylate;3-Methyl-azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester;Methyl 1-Boc-3-Methylazet...;3-Methyl-1,3-azetidinedicarboxylic acid 1-(tert-butyl) 3-methyl ester;1-tert-Butyl 3-Methyl 3-Methylazetidine-1,3-dicarboxylate

Chemical Property of Methyl 1-Boc-3-methylazetidine-3-carboxylate

Chemical Property:

• Boiling Point: 275℃
• PKA: -2.91±0.40(Predicted)
• Flash Point: 120℃
• PSA: 55.84000
• Density: 1.116
• LogP: 1.35430
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-tert-Butyl3-Methyl3-Methylazetidine-1,3-dicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 1-Boc-3-methylazetidine-3-carboxylate

There total 3 articles about Methyl 1-Boc-3-methylazetidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

methyl iodide (74-88-4) → 3-methyl-azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester (898228-37-0)

Guidance literature:

1-[(tert-butoxy)carbonyl]-3-methylazetidine-3-carboxylic acid; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -78 - 0 ℃; for 3.5h;

methyl iodide; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

Reference yield:

azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester (610791-05-4) + methyl iodide (74-88-4) → 3-methyl-azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester (898228-37-0)

Guidance literature:

azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.333333h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 72h;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 1-[(tert-butoxy)carbonyl]-3-methylazetidine-3-carboxylic acid (887591-62-0) → 3-methyl-azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester (898228-37-0)

Guidance literature:

In diethyl ether; dichloromethane; at 0 ℃;

upstream raw materials:

methyl iodide

diazomethane

1-[(tert-butoxy)carbonyl]-3-methylazetidine-3-carboxylic acid

azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester

Downstream raw materials:

methyl 3-methylazetidine-3-carboxylate hydrochloride

3-hydroxymethyl-3-methyl-azetidine-1-carboxylic acid tert-butyl ester