4-BroMobenzofuran-2-carboxylic acid

Base Information

• Chemical Name: 4-BroMobenzofuran-2-carboxylic acid
• CAS No.: 177735-22-7
• Molecular Formula: C9H5BrO3
• Molecular Weight: 241.0382
• Hs Code.: 2932999099
• Mol file: 177735-22-7.mol

Synonyms:4-BroMobenzofuran-2-carboxylic acid;Ethyl 4-broMobenzofuran-2-carboxylate;methyl 4-bromobenzofuran-2-carboxylate

Chemical Property of 4-BroMobenzofuran-2-carboxylic acid

Chemical Property:

• PSA: 39.44000
• LogP: 3.37200

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4-bromo-1-benzofuran-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BroMobenzofuran-2-carboxylic acid

There total 4 articles about 4-BroMobenzofuran-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C11H11BrO4 → ethyl 4-bromobenzofuran-2-carboxylate (177735-22-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 3h;

DOI:10.1016/j.ejmech.2020.112105

Reference yield:

2-bromo-6-hydroxybenzaldehyde (22532-61-2) + chloroacetic acid ethyl ester (105-39-5) → ethyl 4-bromobenzofuran-2-carboxylate (177735-22-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 4h;

Reference yield:

2-bromo-6-hydroxybenzaldehyde (22532-61-2) → ethyl 4-bromobenzofuran-2-carboxylate (177735-22-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium iodide / N,N-dimethyl-formamide / 0.5 h / 10 °C

1.2: 2 h / 10 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 120 °C

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2020.112105

upstream raw materials:

2-bromo-6-hydroxybenzaldehyde

chloroacetic acid ethyl ester

Downstream raw materials:

tert-butyl 4-(2-(ethoxycarbonyl)benzofuran-4-yl)piperazine-1-carboxylate

4-bromobenzofuran-2-carboxylic acid

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