3-Bromo-2-(difluoromethyl)pyridine

Base Information

• Chemical Name: 3-Bromo-2-(difluoromethyl)pyridine
• CAS No.: 1211520-77-2
• Molecular Formula: C₆H₄BrF₂N
• Molecular Weight: 208.005
• Hs Code.: 2933399090
• Mol file: 1211520-77-2.mol

Synonyms:3-Bromo-2-(difluoromethyl)pyridine

Chemical Property of 3-Bromo-2-(difluoromethyl)pyridine

Chemical Property:

• Refractive Index: n20/D1.522
• Flash Point: >110℃
• PSA: 12.89000
• Density: 1.717 g/mL at 25 °C
• LogP: 2.78170
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

3-Bromo-2-(difluoromethyl)pyridine 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromo-2-(difluoromethyl)pyridine

There total 3 articles about 3-Bromo-2-(difluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-bromopicolinaldehyde (405174-97-2) → 3-bromo-2-(difluoromethyl)pyridine (1211520-77-2)

Guidance literature:

With diethylamino-sulfur trifluoride; In chloroform; at 0 - 20 ℃; Solvent; Temperature; Concentration;

Reference yield:

3-bromo-2-picoline (38749-79-0) → 3-bromo-2-(difluoromethyl)pyridine (1211520-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: selenium(IV) oxide / 1,4-dioxane / 18 h / 120 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 2 h / 0 °C / Inert atmosphere

With selenium(IV) oxide; diethylamino-sulfur trifluoride; In 1,4-dioxane; dichloromethane;

Reference yield:

2,3-dibromopyridine (13534-89-9) → 3-bromo-2-(difluoromethyl)pyridine (1211520-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / toluene / 2 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 °C / Inert atmosphere

2.1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / 0 °C / Inert atmosphere

With diethylamino-sulfur trifluoride; tert.-butyl lithium; In dichloromethane; toluene;

upstream raw materials:

3-bromo-2-picoline

3-bromopicolinaldehyde

2,3-dibromopyridine

Downstream raw materials:

[2-(difluoromethyl)pyridin-3-yl]methanol

Refernces

• 1、 -. "PYRIDAZINONES AND METHODS OF USE THEREOF". Page/Page column 321; 322. . Retrieved 2019/04/11.
• 2、 -. "COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES". Page/Page column 134; 135. . Retrieved 2019/07/19.