3-(3-pyridyl)alanine

Base Information

• Chemical Name: 3-(3-pyridyl)alanine
• CAS No.: 28105-69-3
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• Mol file: 28105-69-3.mol

Synonyms:3-Pyridinepropanoic acid, alpha-amino-, (+-)-;

Chemical Property of 3-(3-pyridyl)alanine

Chemical Property:

• Boiling Point: 344.4 °C at 760 mmHg
• Flash Point: 162.1 °C
• Density: 1.271 g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-pyridyl)alanine

There total 15 articles about 3-(3-pyridyl)alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-acetyl-(β-3-pyridyl)-DL-alanine (170092-30-5) → 2-amino-3-(pyridin-3-yl)propanoic acid (17470-24-5,28105-69-3,64090-98-8,70702-47-5)

Guidance literature:

With hydrogenchloride; water; for 3h; Reflux;

DOI:10.1007/s00726-010-0829-3

Reference yield:

3-pyridinecarboxaldehyde (500-22-1) → 2-amino-3-(pyridin-3-yl)propanoic acid (17470-24-5,28105-69-3,64090-98-8,70702-47-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid anhydride; sodium acetate

2: red phosphorus; HI

With phosphorus; hydrogen iodide; sodium acetate; acetic anhydride;

DOI:10.1021/ja01259a059

Reference yield:

Nicotinic acid hydrazide (553-53-7) → 2-amino-3-(pyridin-3-yl)propanoic acid (17470-24-5,28105-69-3,64090-98-8,70702-47-5)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine

2: sodium carbonate; glycerol / 160 °C

3: acetic acid anhydride; sodium acetate

4: red phosphorus; HI

With pyridine; phosphorus; hydrogen iodide; sodium acetate; acetic anhydride; sodium carbonate; glycerol;

DOI:10.1021/ja01259a059

upstream raw materials:

5-[3]pyridylmethylene-imidazolidine-2,4-dione

2-(benzoylamino)-3-(3-pyridinyl)-propanoic acid

3,6-bis-[3]pyridylmethylene-piperazine-2,5-dione

acetic anhydride

Downstream raw materials:

2-pyridin-3-ylethylamine

N-fluorenylmethyloxycarbonyl-3-pyridylalanine-methyl ester

C₂₄H₂₂N₂O₄

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(pyridin-3-yl)propanoic acid

Refernces

• 1、 Lovelock, Sarah L.,Lloyd, Richard C.,Turner, Nicholas J.. "Phenylalanine ammonia lyase catalyzed synthesis of amino acids by an MIO-cofactor independent pathway". supporting information. p. 4652 - 4656. Retrieved 2014/05/20.