3-[2-(diethylamino)ethoxy]aniline

Base Information

• Chemical Name: 3-[2-(diethylamino)ethoxy]aniline
• CAS No.: 34334-19-5
• Molecular Formula: C12H20N2O
• Molecular Weight: 208.304
• Hs Code.: 2922299090
• Mol file: 34334-19-5.mol

Synonyms:3-[2-(diethylamino)ethoxy]aniline;3-(2-(diethylamino)ethoxy)benzenamine

Chemical Property of 3-[2-(diethylamino)ethoxy]aniline

Chemical Property:

• PSA: 38.49000
• LogP: 2.57060

Purity/Quality:

99% ^*data from raw suppliers

3-(2-(DIETHYLAMINO)ETHOXY)ANILINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[2-(diethylamino)ethoxy]aniline

There total 3 articles about 3-[2-(diethylamino)ethoxy]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

→ 3-(2-diethylamino-ethoxy)-phenylamine (34334-19-5)

Guidance literature:

With water; In ethanol; for 3h; Reflux;

Reference yield: 80.0%

N,N-diethyl-1-(3-nitrophenoxy)aminoethane (213606-47-4) → 3-(2-diethylamino-ethoxy)-phenylamine (34334-19-5)

Guidance literature:

With tin(ll) chloride; In ethanol; for 2h; Heating / reflux;

Reference yield:

2-(diethylamino)ethyl chloride (100-35-6) + m-Hydroxyaniline (591-27-5) → 3-(2-diethylamino-ethoxy)-phenylamine (34334-19-5)

Guidance literature:

With sodium hydride; Multistep reaction; 1.) DMF, RT, 2.) DMF, RT;

DOI:10.1021/jm00071a002

upstream raw materials:

2-(diethylamino)ethyl chloride

m-Hydroxyaniline

N,N-diethyl-1-(3-nitrophenoxy)aminoethane

Downstream raw materials:

N-[3-(2-diethylamino-ethoxy)-phenyl]-glycine ethyl ester

Refernces

• 1、 -. "Pyrrolopyrimidine Compounds and Their Uses". Page/Page column 46. . Retrieved 2009/12/28.
• 2、 -. "Novel tricyclic dihydro-quinoline derivatives, method for preparing same and pharmaceutical compositions containing the same". Page/Page column 6. . Retrieved 2010/02/08.