(S)-b-AMino-4-fluorobenzenepropanol

Base Information

• Chemical Name: (S)-b-AMino-4-fluorobenzenepropanol
• CAS No.: 200267-65-8
• Molecular Formula: C9H12FNO
• Molecular Weight: 169.1960832
• Hs Code.: 2922190090
• Mol file: 200267-65-8.mol

Synonyms:(S)-b-AMino-4-fluorobenzenepropanol;(2S)-2-AMINO-3-(4-FLUOROPHENYL)PROPAN-1-OL

Chemical Property of (S)-b-AMino-4-fluorobenzenepropanol

Chemical Property:

• Boiling Point: 307.6±27.0 °C(Predicted)
• PKA: 12.71±0.10(Predicted)
• PSA: 46.25000
• Density: 1.170±0.06 g/cm3(Predicted)
• LogP: 1.38810

Purity/Quality:

99% ^*data from raw suppliers

(S)-2-Amino-3-(4-fluorophenyl)propan-1-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-b-AMino-4-fluorobenzenepropanol

There total 7 articles about (S)-b-AMino-4-fluorobenzenepropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(R)-4-fluorophenylalanine (18125-46-7) → (R)-2-Amino-3-(4-fluorophenyl)-1-propanol (200267-65-8,348619-91-0,64230-78-0)

Guidance literature:

(R)-4-fluorophenylalanine; With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 0 ℃; for 18h; Heating / reflux;

With potassium hydroxide; water; for 4h;

Reference yield: 69.0%

(R)-2-(4-fluorophenyl)glycine (93939-74-3) → (R)-2-Amino-3-(4-fluorophenyl)-1-propanol (200267-65-8,348619-91-0,64230-78-0)

Guidance literature:

(R)-2-(4-fluorophenyl)glycine; With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 0 ℃; for 18h; Heating / reflux;

With methanol; In tetrahydrofuran; at 20 ℃;

Reference yield: 50.0%

ethyl 2-amino-3-(4-fluorophenyl) propanoate (59850-77-0,73283-54-2) → 2-amino-3-(4-fluorophenyl)propan-1-ol (35373-69-4,200267-65-8,348619-91-0,64230-78-0)

Guidance literature:

With sodium tetrahydroborate; lithium chloride; In tetrahydrofuran; ethanol; at 50 - 55 ℃; for 3h;

DOI:10.1021/jm00033a008

upstream raw materials:

ethyl 2-amino-3-(4-fluorophenyl) propanoate

(R)-4-fluorophenylalanine

(R)-2-(4-fluorophenyl)glycine

(R)-4-fluorophenylalanine hydrochloride

Downstream raw materials:

D,L-N-(tert-butoxycarbonyl)-p-fluorophenylalaninol

C₂₃H₂₃FN₄O₆S

2-[4-(4-fluoro-benzyl)-4,5-dihydro-oxazol-2-yl]-3-hydroxy-7-morpholin-4-yl-pyrido[1,2-a]pyrimidin-4-one sodium salt