N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-1-phenylmethanesulfonamide

Base Information

Chemical Name:N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-1-phenylmethanesulfonamide
CAS No.:403604-80-8
Molecular Formula:C₂₂H₁₈ClN₅O₄S
Molecular Weight:0
Hs Code.:
Mol file:403604-80-8.mol

Synonyms:N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-1-phenylmethanesulfonamide

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Chemical Property of N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-1-phenylmethanesulfonamide

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Technology Process of N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-1-phenylmethanesulfonamide

There total 5 articles about N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-1-phenylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 4563-33-1
phenyl-methanesulfonic acid amide

: 150728-13-5
4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

: 403604-80-8
N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-1-phenylmethanesulfonamide

Guidance literature:: phenyl-methanesulfonic acid amide; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;
DOI:10.1016/S0968-0896(01)00187-0

Reference yield:

: 20730-58-9
2-(2-Methoxyphenoxy)propanedioic acid diethyl ester

: 403604-80-8
N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-1-phenylmethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 57 percent / NaOEt / ethanol / 2.75 h / Heating

2.1: 75 percent / phosphorus oxychloride; 2,4,6-trimethylpyrimidine / 17.5 h / 90 °C

3.1: NaH / dimethylformamide / 0.17 h / 20 °C

3.2: 96 percent / dimethylformamide / 4 h / 20 °C

With 2,4,6-trimethylpyrimidine; sodium ethanolate; sodium hydride; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00187-0

Reference yield:

: 329923-15-1
4,6-dihydroxy-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-pyrimidine

: 403604-80-8
N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-1-phenylmethanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 75 percent / phosphorus oxychloride; 2,4,6-trimethylpyrimidine / 17.5 h / 90 °C

2.1: NaH / dimethylformamide / 0.17 h / 20 °C

2.2: 96 percent / dimethylformamide / 4 h / 20 °C

With 2,4,6-trimethylpyrimidine; sodium hydride; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00187-0