4-BROMO-5,7-DICHLOROQUINOLINE

Base Information

• Chemical Name: 4-BROMO-5,7-DICHLOROQUINOLINE
• CAS No.: 203261-25-0
• Molecular Formula: C₉H₄BrCl₂N
• Molecular Weight: 276.947
• Mol file: 203261-25-0.mol

Synonyms:4-BROMO-5,7-DICHLOROQUINOLINE

Chemical Property of 4-BROMO-5,7-DICHLOROQUINOLINE

Chemical Property:

• Vapor Pressure: 3.72E-05mmHg at 25°C
• Boiling Point: 363.7°C at 760 mmHg
• Flash Point: 173.7°C
• PSA: 12.89000
• Density: 1.765g/cm³
• LogP: 4.30410

Purity/Quality:

98% ^*data from raw suppliers

4-BROMO-5,7-DICHLOROQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMO-5,7-DICHLOROQUINOLINE

There total 1 articles about 4-BROMO-5,7-DICHLOROQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methanol (67-56-1) + 4-hydroxy-5,7-dichloroquinoline (171850-29-6,21873-52-9) → 4-bromo-5,7-dichloroquinoline (203261-25-0)

Guidance literature:

With triphenyl phosphite; bromine; In acetonitrile; for 24h;

DOI:10.1002/ps.371

Reference yield:

4-bromo-5,7-dichloroquinoline (203261-25-0) → 5,7-dichloro-4(4-fluorophenoxymethyl)quinoline

Guidance literature:

Multi-step reaction with 4 steps

1: (2-CH₃-C₆H₄)3P; (C₂H₅)3N / Pd(OCOCH₃)2; Cu₂I₂ / acetonitrile / 3 h / Heating

2: 45 percent / O₃; H₂NCSNH₂; CH₂Cl₂ / -78 °C

3: CH₃OH; NaBH₄ / 1 h / 0 °C

4: 60 percent / C₂H₅O₂CN=NCO₂C₂H₅; (C₆H₅)3P / tetrahydrofuran / 20 °C

With methanol; sodium tetrahydroborate; dichloromethane; ozone; triethylamine; thiourea; triphenylphosphine; tris-(o-tolyl)phosphine; diethylazodicarboxylate; palladium diacetate; copper (I) iodide; In tetrahydrofuran; acetonitrile;

DOI:10.1002/ps.371

Reference yield:

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 4-bromo-5,7-dichloroquinoline (203261-25-0) → 5,7-Dichloro-4-((Z)-styryl)-quinoline

Guidance literature:

With triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; copper (I) iodide; In acetonitrile; for 3h; Heating;

DOI:10.1002/ps.371

upstream raw materials:

methanol

4-hydroxy-5,7-dichloroquinoline

Refernces