(2S)-2-Amino-1,5-pentanediol

Base Information

• Chemical Name: (2S)-2-Amino-1,5-pentanediol
• CAS No.: 21946-71-4
• Molecular Formula: C₅H₁₃NO₂
• Molecular Weight: 119.164
• Mol file: 21946-71-4.mol

Synonyms:(2S)-2-Amino-1,5-pentanediol;(S)-2-Amino-1,5-pentanediol;(S)-2-aminopentane-1,5-diol HCl

Chemical Property of (2S)-2-Amino-1,5-pentanediol

Chemical Property:

• Boiling Point: 125-130 °C(Press: 0.1 Torr)
• PKA: 12.79±0.10(Predicted)
• PSA: 66.48000
• Density: 1.081±0.06 g/cm3(Predicted)
• LogP: -0.22120

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-2-Amino-1,5-pentanediol

There total 14 articles about (2S)-2-Amino-1,5-pentanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2S)-benzyl 1,5-dihydroxypentan-2-ylcarbamate (478646-26-3) → (2S)-aminopentan-1,5-diol (21946-71-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 2h; under 2250.23 Torr;

Reference yield: 76.0%

(2S)-[(2-hydroxy-(1R)-phenyl)ethylamino]pentan-1,5-diol (196937-34-5) → (2S)-aminopentan-1,5-diol (21946-71-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 4h; Heating;

Reference yield: 70.0%

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → (2S)-aminopentan-1,5-diol (21946-71-4)

Guidance literature:

L-glutamic acid; With thionyl chloride; In methanol; at 0 - 20 ℃; for 0.5h;

With methanol; potassium borohydride; at 20 ℃; for 24h;

upstream raw materials:

L-glutamic acid diethyl ester

diethyl-L-glutamate hydrochloride

L-glutamic acid dimethyl ester

(2S)-[(2-hydroxy-(1R)-phenyl)ethylamino]pentan-1,5-diol

Downstream raw materials:

(S)-2-(2-hydroxybenzylideneamino)-1,5-pentanediol

(S)-2-(Benzolsulfon-amido)-1,5-diacetyl-mercapto-pentan

Refernces

• 1、 -. "BICYCLIC HETEROCYCLES AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS". Page/Page column 57-58. . Retrieved 2011/04/26.
• 2、 Young, Chun Jung,Cheol, Hwan Yoon,Turos, Edward,Kyung, Soo Yoo,Kyung, Woon Jung. "Total syntheses of (-)-α-kainic acid and (+)-α-allokainic acid via stereoselective C-H insertion and efficient 3,4-stereocontrol". . p. 10114 - 10122. Retrieved 2008/03/28.